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Visugromab

(Synonyms: CTL-002)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

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  • Pureté: 98.40%
  • CAS No.: 2556646-63-8
  • Masse moléculaire:144.56 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Visugromab
  • Experimental Validation Results for Visugromab
  • Experimental Validation Results for Visugromab
  • Experimental Validation Results for Visugromab
  • Experimental Validation Results for Visugromab
  • Visugromab Chemical Structure
    Visugromab Chemical Structure
CAS No.: 2556646-63-8
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized GDF-15 Protein, Human (P.pastoris, His, HY-P75170) can bind Visugromab. The EC50 for this effect is 5.159 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HeLa cells with Visugromab (HY-P99100, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.

  • 1/16

    Visugromab purchased from MedChemExpress. Usage Cited in: Mol Cell Biochem. 2024 May 14. [Abstract]

    Customer Validation
     GDF-15 protein level measured by ELISA in CM following 1h incubation with different concentrations of Visugromab (0.625-20 μg/mL). 20 μg/mL was selected as the effective neutralization concentration.

  • 1/16

    Visugromab purchased from MedChemExpress. Usage Cited in: Mol Cell Biochem. 2024 May 14. [Abstract]

    Customer Validation
     The quantification of EdU positive nuclei as a percentage of all nuclei for hAdv cultured in control conditions (hAdv) or in the presence of Visugromab (20 μg/ml) in culture medium. Addition of Visugromab directly to hAdv cells culture medium resulted in decreased proliferation rate of the cells.

  • Visugromab Chemical Structure
    1/16
  • Visugromab
  • Immobilized GDF-15 Protein, Human (P.pastoris, His, HY-P75170) can bind Visugromab. The EC50 for this effect is 5.159 ng/mL.
  • Flow cytometric analysis of 1X106 HeLa cells with Visugromab (HY-P99100, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.