VPC12249
VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 403520-23-0
- Formule: C34H52NO6P
- Masse moléculaire:601.75
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
>10000 nM
Compound: 14a
|
In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines
In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines
|
[PMID: 15125924] |
| HEK-293T | IC50 |
>10000 nM
Compound: 14a
|
In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines
In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines
|
[PMID: 15125924] |
| HEK-293T | IC50 |
5210 nM
Compound: 20
|
Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells
Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells
|
10.1039/C4MD00333K |
| HEK-293T | IC50 |
6450 nM
Compound: 20
|
Antagonist activity at human LPA3 receptor transfected in HEK293T cells
Antagonist activity at human LPA3 receptor transfected in HEK293T cells
|
10.1039/C4MD00333K |
Chemical Information
-
CAS No. 403520-23-0
-
Masse moléculaire 601.75
-
Formule C34H52NO6P
-
SMILES
CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)COP(O)(O)=O)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VPC12249 Related Classifications
HY-129808 Related Classifications
Powered by Bioz