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Cat. No.: HY-105345

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WRC-0571

WRC-0571 is an orally effective, potent, and selective non-xanthine adenosine A₁ receptor antagonist with a K_i value of 1.7 nM for the human A₁ receptor. WRC-0571 competitively binds to and blocks adenosine A₁ receptor, thereby inhibiting downstream signaling and physiological responses. WRC-0571 can be used for research on bradycardia.

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CAS No.: 175097-37-7
Formule: C₁₇H₂₆N₆O
Masse moléculaire:330.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

WRC-0571 Chemical Structure

CAS No.: 175097-37-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Description

IC₅₀ & Target

^[3]

human A1

1.7 nM (Ki)

rat A1

1.1 nM (Ki)

hA₃

7940 nM (Ki)

Voir tous les produits spécifiques à Isoform Adenosine Receptor :

In Vitro

WRC-0571 (1 μM) is a highly A₁-selective antagonist that completely blocks A₁ receptors in guinea pig brain but does not block A₃ receptors in guinea pig, hamster, cat, and human pineal gland membranes^[1].
WRC-0571 (2.5 h) binds to recombinant rat A₃ adenosine receptors with an IC₅₀ of 23.2 μM in HEK-293 cell membranes^[1].
WRC-0571 (1 μM) does not block A₃AR-mediated Akt phosphorylation in RBL-2H3 cells^[2].
WRC-0571 is a potent non-xanthine A₁ antagonist with high affinity for the human A₁ receptor (K_i = 1.7 nM) and 200-fold selectivity over the A_2A receptor^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 175097-37-7
Masse moléculaire 330.43
Formule C₁₇H₂₆N₆O
SMILES

CC(C)N(C)C1=NC(C(N[C@H]2[C@@H]3C[C@@H]([C@H](O)C3)C2)=NC=N4)=C4N1C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Jin X, et al. Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. The Journal of clinical investigation. 1997 Dec 01;100(11):2849-57.

[2]. Gao Z, et al. A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Mol Pharmacol. 2001;59(1):76-82.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
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Chemical Information
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WRC-0571

Voir tous les produits spécifiques à Isoform Adenosine Receptor

Activité biologique

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IC50 & Target

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