XL-281
XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 870603-16-0
- Formule: C24H19ClN4O4
- Masse moléculaire:462.89
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
C-Raf 2.6 nM (IC50) |
B-Raf 4.5 nM (IC50) |
B-RafV600E 6 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SK-MEL19 | IC50 |
200 nM
Compound: 8; XL281; BMS-908662
|
Cytotoxicity against human SK-MEL-19 cells harboring BRAF mutant after 3 days
Cytotoxicity against human SK-MEL-19 cells harboring BRAF mutant after 3 days
|
[PMID: 29461827] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 870603-16-0
-
Masse moléculaire 462.89
-
Formule C24H19ClN4O4
-
SMILES
O=C(OC)NC1=NC2=CC=C(C3(O)N(C4=CC(Cl)=CC=C4C)C(C5=C3C=CC=C5)=O)C=C2N1
-
Synonyms
BMS-908662
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XL-281 Related Classifications
HY-19343 Related Classifications
Powered by Bioz