Ziconotide
Based on 2 publication(s) in Google Scholar
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.
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- CAS No.: 107452-89-1
- Formule: C102H172N36O32S7
- Masse moléculaire:2639.13
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Ziconotide
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Activité biologique
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N-type calcium channel |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | IC50 |
0.5 μM
Compound: omega-Conotoxin
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In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
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[PMID: 15537361] |
| PC-12 | IC50 |
0.6 μM
Compound: omega-Conotoxin
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In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
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[PMID: 15537361] |
Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
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Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
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Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
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Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
Chemical Information
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CAS No. 107452-89-1
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Masse moléculaire 2639.13
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Formule C102H172N36O32S7
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Synonyms
SNX-111
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Sequence Shortening
CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
PCIF1-mediated m6Am modification in ACC neurons participates in inflammatory pain and anxiety. [Abstract]2026 Feb 18;45(3):117016. PMID: 41712381 -
Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281
Pureté et documentation
Références
[1]. Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85. [Content Brief]
[2]. Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ziconotide Related Classifications
HY-P0062 Related Classifications
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