ZL-Pin13
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.87%
- CAS No.: 2883498-73-3
- Formule: C24H23ClN2O3S
- Masse moléculaire:454.97
-
Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
2.8 μM
Compound: ZL-Pin13
|
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 35089030] |
| MDA-MB-468 | IC50 |
1.9 μM
Compound: ZL-Pin13
|
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 35089030] |
Chemical Information
-
CAS No. 2883498-73-3
-
Appearance Solid
-
Masse moléculaire 454.97
-
Formule C24H23ClN2O3S
-
Color White to off-white
-
SMILES
O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureté et documentation
-
Fiche technique (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)