2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Carazolol

Carazolol  (Synonyms: (±)-Carazolol; DL-Carazolol; Suacron)

Cat. No.: HY-107327 Purity: 99.71%
COA Handling Instructions

Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist.

For research use only. We do not sell to patients.

Carazolol Chemical Structure

Carazolol Chemical Structure

CAS No. : 57775-29-8

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10 mg USD 80 In-stock
25 mg USD 160 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Carazolol:

Carazolol Related Antibodies

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].

IC50 & Target

β1 adrenoceptor

 

β2 adrenoceptor

 

β3 adrenoceptor

 

In Vivo

Carazolol (0.01 mg/kg; i.m.; once) shows no significant side effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kivircik sheeps, 25-45 kg, nonpregnant[2]
Dosage: 0.01 mg/kg
Administration: Intramuscular injection, once
Result: Urea, creatinin, ALT, ALP, GGT, LDH, Ca, P, T.Protein, Mg, Cu levels in blood serum parameters were found to be in normal level however serum Fe, Zn levels were decreased.
Molecular Weight

298.38

Appearance

Solid

Formula

C18H22N2O2
CAS No.
SMILES

CC(C)NCC(O)COC1=CC=CC2=C1C3=CC=CC=C3N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (335.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3514 mL 16.7572 mL 33.5143 mL
5 mM 0.6703 mL 3.3514 mL 6.7029 mL
10 mM 0.3351 mL 1.6757 mL 3.3514 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.71%

COA (246 KB) HNMR (138 KB) RP-HPLC (238 KB)

Handling Instructions (2659 KB)
References
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Carazolol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Carazolol57775-29-8(±)-Carazolol DL-Carazolol SuacronAdrenergic ReceptorBeta ReceptorSelectiveAgonistAntagonistInhibitorinhibitorinhibit

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