2. Apoptosis
  3. Caspase Apoptosis
  4. Caspase-3/7 Inhibitor I

Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes.

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Caspase-3/7 Inhibitor I

Caspase-3/7 Inhibitor I Estructura química

No. CAS : 1110670-49-9

Tamaño Precio Stock Cantidad
Powder + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Powder
1 mg En stock
5 mg En stock
10 mg   Obtener un presupuesto  
50 mg   Obtener un presupuesto  

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Caspase-3/7 Inhibitor I Related Antibodies

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Descripciòn

Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes[1][2].

Peso molecular

324.35

Fòrmula

C14H16N2O5S
No. CAS
Appearance

Powder

Color

yellow

SMILES

O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (308.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0831 mL 15.4154 mL 30.8309 mL
5 mM 0.6166 mL 3.0831 mL 6.1662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0831 mL 15.4154 mL 30.8309 mL 77.0772 mL
5 mM 0.6166 mL 3.0831 mL 6.1662 mL 15.4154 mL
10 mM 0.3083 mL 1.5415 mL 3.0831 mL 7.7077 mL
15 mM 0.2055 mL 1.0277 mL 2.0554 mL 5.1385 mL
20 mM 0.1542 mL 0.7708 mL 1.5415 mL 3.8539 mL
25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0831 mL
30 mM 0.1028 mL 0.5138 mL 1.0277 mL 2.5692 mL
40 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9269 mL
50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2846 mL
80 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9635 mL
100 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
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Caspase-3/7 Inhibitor I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caspase-3/7 Inhibitor I1110670-49-9CaspaseApoptosisInhibitorinhibitorinhibit

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Nombre del producto:
Caspase-3/7 Inhibitor I
Cat. No.:
HY-W033813
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