Caspase-3/7 Inhibitor I
Based on 1 Customer Validation
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes.
For research use only. We do not sell to patients.
- Purity: 98.31%
- CAS No.: 1110670-49-9
- Formula: C14H16N2O5S
- Molecular Weight:324.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
Chemical Information
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CAS No. 1110670-49-9
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Appearance Powder
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Molecular Weight 324.35
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Formula C14H16N2O5S
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Color yellow
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SMILES
O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (308.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000 May 26;275(21):16007-14. [Content Brief]
[2]. Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0831 mL | 15.4154 mL | 30.8309 mL | 77.0772 mL |
| 5 mM | 0.6166 mL | 3.0831 mL | 6.1662 mL | 15.4154 mL | |
| 10 mM | 0.3083 mL | 1.5415 mL | 3.0831 mL | 7.7077 mL | |
| 15 mM | 0.2055 mL | 1.0277 mL | 2.0554 mL | 5.1385 mL | |
| 20 mM | 0.1542 mL | 0.7708 mL | 1.5415 mL | 3.8539 mL | |
| 25 mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 3.0831 mL | |
| 30 mM | 0.1028 mL | 0.5138 mL | 1.0277 mL | 2.5692 mL | |
| 40 mM | 0.0771 mL | 0.3854 mL | 0.7708 mL | 1.9269 mL | |
| 50 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5415 mL | |
| 60 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2846 mL | |
| 80 mM | 0.0385 mL | 0.1927 mL | 0.3854 mL | 0.9635 mL | |
| 100 mM | 0.0308 mL | 0.1542 mL | 0.3083 mL | 0.7708 mL |
Caspase-3/7 Inhibitor I Related Classifications
HY-W033813 Related Classifications
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