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Cat. No.: HY-143460

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CAXII-IN-1

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with K_i values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2479918-59-5
Formula: C₁₃H₇Cl₂NO₃S
Molecular Weight:328.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CAXII-IN-1 Chemical Structure

CAS No.: 2479918-59-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with K_i values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity^[1].

IC₅₀ & Target

IC₅₀: 3.8 nM (hCA XII), 56.0 nM (hCA IX)^[1]

All Carbonic Anhydrase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14 μM Compound: 17	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]
HeLa	IC₅₀	4.8 μM Compound: 17	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]
MCF7	IC₅₀	20 μM Compound: 17	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]

In Vitro

CAXII-IN-1 (Compound 17) shows cytotoxicity with IC₅₀ values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2479918-59-5
Molecular Weight 328.17
Formula C₁₃H₇Cl₂NO₃S
SMILES

ClC1=CC(Cl)=CC(C2=CN=C(OS(C=C3)(=O)=O)C3=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CAXII-IN-1

All Carbonic Anhydrase Isoforms