CCR6 antagonist 1

Name: CCR6 antagonist 1
Brand: MedChemExpress
SKU: HY-151435
Rating: 5.0 (4 reviews)

製品番号: HY-151435 純度: 99.30%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 588674-64-0

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 99	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$90	在庫あり	Estimated Time of Arrival: December 31
10 mg	$140	在庫あり	Estimated Time of Arrival: December 31
25 mg	$290	在庫あり	Estimated Time of Arrival: December 31
50 mg	$420	在庫あり	Estimated Time of Arrival: December 31
100 mg	$650	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

顧客検証

Others

Cell Migration/Invasion Assay

: CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 13;16(1):2493. [Abstract]; CCR6 antagonist 1 (50 μM). The effects of the inhibitor on each pathway were assessed by IPA analysis, and its effect on HE cell expansion after 7 days was observed.

: CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Transl Res. 2025 Sep 11:S1931-5244(25)00089-1. [Abstract]; The number of migrating NCAPB and DSSAPB cells with or without CCR6 antagonist 1 treatment.

: CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111332. [Abstract]; Transwell migration assay: PBMCs isolated from MPE patients were placed in the upper chamber, and different conditions (medium, PE, MPE, MPE + CCR2 antagonist, MPE + CCR5 antagonist, or MPE + CCR6 antagonist 1 (20 μg/mL) ) were placed in the lower chamber.

CCR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

CCR6

体外実験

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4⁺ T cell migration^[1].
? CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:	CCL20 (500 ng/mL)-induced CCR6⁺CD4⁺ T cell
Concentration:	0.5, 5, 50 μM
Incubation Time:	3 h
Result:	Inhibited CCL20-induced cell migration at 50 μM.

体内実験

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice^[1].
? CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine model of colitis (5 mg/mouse TNBS-induced)^[1]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection (s.c.), twice daily for 3 days.
Result:	Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.

Animal Model:	Zymosan-induced peritonitis mice^[1]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result:	Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.

分子量

319.28

分子式

C₁₇H₁₂F₃NO₂

CAS 番号

588674-64-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C2=CC=CC=C2O1)NC3=CC=C(C(F)(F)F)C=C3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1320 mL	15.6602 mL	31.3205 mL
5 mM	0.6264 mL	3.1320 mL	6.2641 mL
10 mM	0.3132 mL	1.5660 mL	3.1320 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (3.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.30%

Select Batch:

データシート (276 KB) SDS (251 KB)

COA (246 KB) HNMR (259 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1320 mL	15.6602 mL	31.3205 mL	78.3012 mL
	5 mM	0.6264 mL	3.1320 mL	6.2641 mL	15.6602 mL
	10 mM	0.3132 mL	1.5660 mL	3.1320 mL	7.8301 mL
	15 mM	0.2088 mL	1.0440 mL	2.0880 mL	5.2201 mL
	20 mM	0.1566 mL	0.7830 mL	1.5660 mL	3.9151 mL
	25 mM	0.1253 mL	0.6264 mL	1.2528 mL	3.1320 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6100 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9575 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5660 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3050 mL
	80 mM	0.0392 mL	0.1958 mL	0.3915 mL	0.9788 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7830 mL