2. PI3K/Akt/mTOR
  3. Akt
  4. CCT129254

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo.

For research use only. We do not sell to patients.

CCT129254

CCT129254 Chemical Structure

CAS No. : 885500-12-9

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CCT129254 Related Antibodies

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Description

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
5235 nM
Compound: 3
Inhibition of human ERG expressed in CHO cells by ionworks assay
Inhibition of human ERG expressed in CHO cells by ionworks assay
[PMID: 23394218]
MDA-MB-468 IC50
328 nM
Compound: 3
Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry
Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry
[PMID: 23394218]
PC-3M IC50
> 50 nM
Compound: 21, CCT129524
Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay
Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay
[PMID: 20151677]
U-87MG ATCC GI50
0.93 nM
Compound: 21, CCT129524
Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA
Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA
[PMID: 20151677]
U-87MG ATCC IC50
17 nM
Compound: 21, CCT129524
Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay
Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay
[PMID: 20151677]
Molecular Weight

384.86

Formula

C19H21ClN6O
CAS No.
SMILES

ClC1=CC=C(CNC(C2(N)CCN(C3=NC=NC4=C3C=CN4)CC2)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCT129254 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT129254885500-12-9AT 11854CCT 129254CCT-129254AT11854AT-11854AktPKBProtein kinase BAGC kinasesAKTInhibitorinhibitorinhibit

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