Art. -Nr.: HY-137335

6'-Sialyllactose sodium

1 Cited Publications

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6'-Sialyllactose sodium promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose sodium exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose sodium promotes the muscle health.

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Reinheit: 98.05%
CAS. Nr.: 157574-76-0
Formel: C₂₃H₃₈NNaO₁₉
Molecular Weight:655.53

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

6'-Sialyllactose sodium Chemical Structure

CAS. Nr.: 157574-76-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

In Vitro

6'-Sialyllactose sodium (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

HUVEC
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Downregulated levels of p-Akt and p-ERK.

In Vivo

6'-Sialyllactose sodium (5% added to mouse diet, 2 weeks) alleviates the anxiety-like behavior of mice, regulates the flora composition in social disruption (SDR)-stressed mouse model^[2].
6'-Sialyllactose sodium (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SDR-stressed mouse model^[2]
Dosage:

5% added to mouse diet
Administration:

po, 2 weeks
Result:

Reduced the anxiety-like behavior in open field tests.
Maintained the number of DCX-positive cells in the hippocampus.

Animal Model:

C57BL/6J mouse models^[3]
Dosage:

100 mg/kg
Administration:

po, once daily, 5 times a week for 12 weeks
Result:

Increased the mouse running distance.
Increased the absolute weight of gastrocnemius and soleus muscles.

Chemical Information

CAS. Nr. 157574-76-0
Appearance Solid
Molecular Weight 655.53
Formel C₂₃H₃₈NNaO₁₉
Color White to off-white
SMILES

O=C([C@](O[C@@]([C@@H]1NC(C)=O)([H])[C@H](O)[C@H](O)CO)(C[C@@H]1O)OC[C@H]([C@@H]([C@@H]2O)O)O[C@H]([C@@H]2O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[Na]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Future Sci OA

The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]

2026 Dec;12(1):2622241. PMID: 41622772

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (152.55 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5255 mL

7.6274 mL

15.2548 mL

5 mM

0.3051 mL

1.5255 mL

3.0510 mL

10 mM

0.1525 mL

0.7627 mL

1.5255 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 12.5 mg/mL (19.07 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. MariarosariaMarotta, et al. The predominant milk oligosaccharide 6′-sialyllactose reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes. Journal of Functional Foods Volume 6, January 2014, Pages 367-373.

[2]. Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177. [Content Brief]

[3]. Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. [Content Brief]

[4]. Kim EY, et al., 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis. BMB Rep. 2019 Sep;52(9):560-565. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5255 mL	7.6274 mL	15.2548 mL	38.1371 mL
	5 mM	0.3051 mL	1.5255 mL	3.0510 mL	7.6274 mL
	10 mM	0.1525 mL	0.7627 mL	1.5255 mL	3.8137 mL
	15 mM	0.1017 mL	0.5085 mL	1.0170 mL	2.5425 mL
	20 mM	0.0763 mL	0.3814 mL	0.7627 mL	1.9069 mL
	25 mM	0.0610 mL	0.3051 mL	0.6102 mL	1.5255 mL
	30 mM	0.0508 mL	0.2542 mL	0.5085 mL	1.2712 mL
	40 mM	0.0381 mL	0.1907 mL	0.3814 mL	0.9534 mL
	50 mM	0.0305 mL	0.1525 mL	0.3051 mL	0.7627 mL
	60 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6356 mL
	80 mM	0.0191 mL	0.0953 mL	0.1907 mL	0.4767 mL
	100 mM	0.0153 mL	0.0763 mL	0.1525 mL	0.3814 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

6'-Sialyllactose sodium

1 Cited Publications

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6'-Sialyllactose sodium

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Publications Citing Use of MedChemExpress (MCE) 6'-Sialyllactose sodium

Alle VEGFR Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

6'-Sialyllactose sodium Related Classifications

HY-137335 Related Classifications