KDOAM-25
Based on 9 publication(s) in Google Scholar
KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.
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- CAS. Nr.: 2230731-99-2
- Formel: C15H25N5O2
- Molecular Weight:307.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) KDOAM-25
More- Nat Cell Biol. 2024 Feb;26(2):263-277. [Abstract]
- Sci Adv. 2025 Jun 6;11(23):eadu2695. [Abstract]
- Clin Transl Med. 2024 Jun;14(6):e1692. [Abstract]
- Oncol Rep. 2026 Apr;55(4):79. [Abstract]
- Clin Exp Med. 2025 Nov 25;26(1):33. [Abstract]
- Cancer Res Commun. 2026 Mar 1;6(3):616-629. [Abstract]
- bioRxiv. 2024 October 03.
- Research Square Preprint. 2023 Dec 2.
- University of Gothenburg. 2023 Jun 27.
Biologische Aktivität
IC50: 71 nM (KDM5A), 19 nM (KDM5B), 69 nM (KDM5C), 69 nM (KDM5D)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | EC50 |
>50 μM
Compound: 15
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Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability
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[PMID: 34555614] |
| MM1.S | IC50 |
30 μM
Compound: 11d
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Cytotoxicity against human MM1.S cells assessed as inhibition of cell growth
Cytotoxicity against human MM1.S cells assessed as inhibition of cell growth
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[PMID: 32883639] |
KDOAM-25 inhibits most potently KDM5B with an IC50 of ∼50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 shows no cellular activity on any of the other tested JmjC family members[1].
KDOAM-25 is able to reduce the viability of MM1S cells with an IC50 of ∼30 μM after a delay of 5-7 days[1].
KDOAM-25 treatment results in a G1 cell-cycle arrest with an increased proportion of MM1S in G1 and a decrease of the proportion of cells in G2 without an increase in the proportion of cells in the apoptotic sub-G1 phase[1].
KDOAM-25 (50 μM) increases with approximately twice as much H3K4me3 in in multiple myeloma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2230731-99-2
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Molecular Weight 307.39
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Formel C15H25N5O2
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SMILES
NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest. [Abstract]2024 Feb;26(2):263-277. PMID: 38238450 -
Sci Adv
Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform. [Abstract]2025 Jun 6;11(23):eadu2695. PMID: 40479052 -
Clin Transl Med
Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer. [Abstract]2024 Jun;14(6):e1692. PMID: 38804602 -
Oncol Rep
2026 Apr;55(4):79. PMID: 41789643 -
Clin Exp Med
Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]2025 Nov 25;26(1):33. PMID: 41286164 -
Cancer Res Commun
Mutant Isocitrate Dehydrogenase 1 Sensitizes Intrahepatic Cholangiocarcinoma Cells to MDM2 Inhibitors. [Abstract]2026 Mar 1;6(3):616-629. PMID: 41747217 -
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Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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