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Art. -Nr.: HY-10216

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Refametinib (R enantiomer)

Name: Refametinib (R enantiomer)
Brand: MedChemExpress
SKU: HY-10216
Price: 70.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: BAY 869766 R enantiomer; RDEA119 R enantiomer)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC₅₀ of 2.0-15 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 923032-38-6
Formel: C₁₉H₂₀F₃IN₂O₅S
Molecular Weight:572.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Refametinib (R enantiomer) Chemical Structure

CAS. Nr.: 923032-38-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC₅₀ of 2.0-15 nM.

IC₅₀ & Target

^[1]

MEK

2-15 nM (EC₅₀)

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In Vitro

Refametinib R enantiomer is the R enantiomer of Refametinib . Refametinib R enantiomer is an inhibitor of MEK and is useful in treatment of cancer and other hyperproliferative diseases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 923032-38-6
Molecular Weight 572.34
Formel C₁₉H₂₀F₃IN₂O₅S
SMILES

O=S(C1(C[C@H](CO)O)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O
Synonyms

BAY 869766 R enantiomer; RDEA119 R enantiomer
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Sci Adv

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. [Abstract]

2019 Aug 14;5(8):eaav8463. PMID: 31453322

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Andreas Maderna, et al. N-(arylamino)-sulfonamide inhibitors of mek. WO 2007014011 A2.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Refametinib (R enantiomer)

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

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Refametinib (R enantiomer)

Publications Citing Use of MedChemExpress (MCE) Refametinib (R enantiomer)

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