Art. -Nr.: HY-N0367

Trans-Anethole

(Synonyms: (E)-Anethole)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor.

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Reinheit: 99.48%
CAS. Nr.: 4180-23-8
Formel: C₁₀H₁₂O
Molecular Weight:148.21

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Trans-Anethole Chemical Structure

CAS. Nr.: 4180-23-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Trans-Anethole (0.25-2 mM; 3 h) causes concentration and time-dependent cell death in isolated rat hepatocytes at doses greater than 1 mM^[2].
Trans-Anethole (0.25-1 mM; 3 h) produces metabolites 4MCA and 4OHPB sulfate that increases over time in isolated rat hepatocytes cultured at 0.5 and 1 mM doses, while metabolite 4OHPB increases over time only at 1 mM dose^[2].
Trans-Anethole (0.5, 1 mM; 3 h) enhances and accelerates the killing of rat hepatocytes in vitro by DCNP (50 mM) and the loss of cellular ATP^[2].
Trans-Anethole (0.1 mM; 6 d) has a certain degree of cytotoxicity against human breast cancer MCF-7 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

MCF-7 cells
Concentration:

0.1 mM
Incubation Time:

6 d
Result:

Reduced cell viability by 80% compared to untreated cells.

In Vivo

Punicic acid (10, 30, 100 mg/kg, p.o.; once daily for 5 days) shows antithrombotic activity in male Swiss mice at a dose of 30 mg/kg^[4].
Punicic acid (80 mg/kg, p.o.; once daily for 45 days) normalizes the levels of glucose metabolizing enzymes in the liver and kidney and improves the liver and muscle glycogen content in Streptozotocin (HY-13753) induced diabetic rats^[5].
Punicic acid (80 mg/kg, p.o.; once daily for 1-8 days) causes impaired hormonal balance, impaires implantation, and dose-dependent inhibition of pregnancy in adult albino rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

streptozotocin induced diabetic rats^[5].
Dosage:

20, 40, 80 mg/kg
Administration:

45 d
Result:

Inhibited the increase of blood sugar and significantly reverse the insulin level, and the effect is more significant at a dose of 80 mg/kg.
Restored the activities of hexokinase and glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver tissue of diabetic rats to normal levels at a dose of 80 mg/kg.
Prevented the decrease of glycogen content in the liver and muscles at a dose of 80 mg/kg.

Chemical Information

CAS. Nr. 4180-23-8
Appearance <20°C Solid,>21°C Liquid
Molecular Weight 148.21
Formel C₁₀H₁₂O
Color White to yellow
SMILES

COC1=CC=C(/C=C/C)C=C1
Synonyms

(E)-Anethole
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
Initial Source
- Plants
- Umbelliferae
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

PLoS Biol

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. [Abstract]

2024 Jun 27;22(6):e3002672. PMID: 38935621
bioRxiv

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]

2024 Apr 3:2023.06.02.542933. PMID: 37333363

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (674.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7472 mL

33.7359 mL

67.4718 mL

5 mM

1.3494 mL

6.7472 mL

13.4944 mL

10 mM

0.6747 mL

3.3736 mL

6.7472 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (337.36 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tabanca N, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med. 2004 Aug;70(8):728-35. [Content Brief]

[2]. Nakagawa Y, et al. Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Jul 1;66(1):63-73. [Content Brief]

[3]. Fahlbusch, et al. "Flavors and Fragrances", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH.

[4]. Tognolini M, et al. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacological Research 2007; 56: 254-260. [Content Brief]

[5]. Sheikh, et al. Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Biochimie 112 (2015): 57-65. [Content Brief]

[6]. Dhar, et al. Anti-fertility activity and hormonal profile of trans-anethole in rats. Indian journal of physiology and pharmacology 39 (1995): 63-63. [Content Brief]

[7]. JD Lei, et al. "Antifungal effects of trans-anethole, the main constituent of Illicium verum fruit volatiles, on Aspergillus flavus in stored wheat." Food Control 149 (2023): 109721.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.7472 mL	33.7359 mL	67.4718 mL	168.6796 mL
	5 mM	1.3494 mL	6.7472 mL	13.4944 mL	33.7359 mL
	10 mM	0.6747 mL	3.3736 mL	6.7472 mL	16.8680 mL
	15 mM	0.4498 mL	2.2491 mL	4.4981 mL	11.2453 mL
	20 mM	0.3374 mL	1.6868 mL	3.3736 mL	8.4340 mL
	25 mM	0.2699 mL	1.3494 mL	2.6989 mL	6.7472 mL
	30 mM	0.2249 mL	1.1245 mL	2.2491 mL	5.6227 mL
	40 mM	0.1687 mL	0.8434 mL	1.6868 mL	4.2170 mL
	50 mM	0.1349 mL	0.6747 mL	1.3494 mL	3.3736 mL
	60 mM	0.1125 mL	0.5623 mL	1.1245 mL	2.8113 mL
	80 mM	0.0843 mL	0.4217 mL	0.8434 mL	2.1085 mL
	100 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.6868 mL

Keywords

Trans-Anethole

2 Cited Publications

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Trans-Anethole

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Publications Citing Use of MedChemExpress (MCE) Trans-Anethole

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Trans-Anethole Related Classifications

HY-N0367 Related Classifications