MYC degrader 1
Based on 1 publication(s) in Google Scholar
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors.
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- Reinheit: 99.61%
- CAS. Nr.: 2946670-96-6
- Formel: C32H31ClF3N5O3
- Molecular Weight:626.07
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MYC degrader 1
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Biologische Aktivität
MYC degrader 1 (0-1000 nM; 24 h) degrades MYC in T24, C4-2, MDA-MB-231, 22RV1,T47D and UMUC14 cell lines[1].
MYC degrader 1 (10 nM; 24 h) treatment of T24 and UMUC14 cells significantly reduces the IC50 of Palbociclib (HY-50767) from 8.37 and 97.39 to 3.11 and 10.23 μM, respectively[1].
MYC degrader 1 (10 nM; 24 h) enhances the inhibition of cell cycle genes and colony formation by Palbociclib (HY-50767) in drug-resistant cancer cell lines T24, C4-2 MDA-MB-231[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T24, C4-2, MDA-MB-231, 22RV1, T47D and UMUC14 cell lines
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Concentration:0, 10, 25, 50, 100, 500 and 1000 nM
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Incubation Time:24 h
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Result:Reduced KLHL42 levels and increased RB1 levels.
MYC degrader 1 (6 mg/kg; i.g.; once daily for 30 days) enhances the inhibitory effect of Palbociclib (HY-50767) on tumor growth in T24 xenograft mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2946670-96-6
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Appearance Solid
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Molecular Weight 626.07
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Formel C32H31ClF3N5O3
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Color White to off-white
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SMILES
ClC1=CC(C2=CC(C(F)(F)F)=C(N3CCC(CNCC4=CC(CN(C5C(NC(CC5)=O)=O)C6=O)=C6C=C4)CC3)N=C2)=CC=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
BCR::ABL1-Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B-ALL Cells to Enhancer-Targeting Drugs. [Abstract]2026 Mar 1:e17231. PMID: 41764406
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (159.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5973 mL | 7.9863 mL | 15.9727 mL | 39.9316 mL |
| 5 mM | 0.3195 mL | 1.5973 mL | 3.1945 mL | 7.9863 mL | |
| 10 mM | 0.1597 mL | 0.7986 mL | 1.5973 mL | 3.9932 mL | |
| 15 mM | 0.1065 mL | 0.5324 mL | 1.0648 mL | 2.6621 mL | |
| 20 mM | 0.0799 mL | 0.3993 mL | 0.7986 mL | 1.9966 mL | |
| 25 mM | 0.0639 mL | 0.3195 mL | 0.6389 mL | 1.5973 mL | |
| 30 mM | 0.0532 mL | 0.2662 mL | 0.5324 mL | 1.3311 mL | |
| 40 mM | 0.0399 mL | 0.1997 mL | 0.3993 mL | 0.9983 mL | |
| 50 mM | 0.0319 mL | 0.1597 mL | 0.3195 mL | 0.7986 mL | |
| 60 mM | 0.0266 mL | 0.1331 mL | 0.2662 mL | 0.6655 mL | |
| 80 mM | 0.0200 mL | 0.0998 mL | 0.1997 mL | 0.4991 mL | |
| 100 mM | 0.0160 mL | 0.0799 mL | 0.1597 mL | 0.3993 mL |
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