Amorolfine
Based on 1 publication(s) in Google Scholar
Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candida albicans with a MIC of 0.404 µg/mL.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 78613-35-1
- Formel: C21H35NO
- Molecular Weight:317.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Amorolfine
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 78613-35-1
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Molecular Weight 317.51
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Formel C21H35NO
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SMILES
C[C@H]1O[C@H](CN(C1)CC(CC2=CC=C(C=C2)C(C)(CC)C)C)C
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Synonyms
Ro 14-4767; Ro 14-4767/000
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (314.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.75 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (15.75 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
Verweise
[1]. Pittrof F, et al., Loceryl nail lacquer--realization of a new galenical approach to onychomycosis therapy. Clin Exp Dermatol. 1992 Sep;17 Suppl 1:26-8. [Content Brief]
[2]. Haria M, et al. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995 Jan;49(1):103-20. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1495 mL | 15.7475 mL | 31.4951 mL | 78.7377 mL |
| 5 mM | 0.6299 mL | 3.1495 mL | 6.2990 mL | 15.7475 mL | |
| 10 mM | 0.3150 mL | 1.5748 mL | 3.1495 mL | 7.8738 mL | |
| 15 mM | 0.2100 mL | 1.0498 mL | 2.0997 mL | 5.2492 mL | |
| 20 mM | 0.1575 mL | 0.7874 mL | 1.5748 mL | 3.9369 mL | |
| 25 mM | 0.1260 mL | 0.6299 mL | 1.2598 mL | 3.1495 mL | |
| 30 mM | 0.1050 mL | 0.5249 mL | 1.0498 mL | 2.6246 mL | |
| 40 mM | 0.0787 mL | 0.3937 mL | 0.7874 mL | 1.9684 mL | |
| 50 mM | 0.0630 mL | 0.3150 mL | 0.6299 mL | 1.5748 mL | |
| 60 mM | 0.0525 mL | 0.2625 mL | 0.5249 mL | 1.3123 mL | |
| 80 mM | 0.0394 mL | 0.1968 mL | 0.3937 mL | 0.9842 mL | |
| 100 mM | 0.0315 mL | 0.1575 mL | 0.3150 mL | 0.7874 mL |
Amorolfine Related Classifications
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