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Art. -Nr.: HY-182782

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Analgesic agent-4

Analgesic agent-4 is an adenosine A₃AR ligand with analgesic/antinociceptive activity. Analgesic agent-4 inhibits writhing responses in mice and exhibits dose-dependent activity in the acetic acid (HY-Y0319)-induced mouse writhing model. Analgesic agent-4 can be used in the research of pain-related diseases.

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CAS. Nr.: 1179703-17-3
Formel: C₁₁H₈ClN₃O₂
Molecular Weight:249.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Analgesic agent-4 Chemical Structure

CAS. Nr.: 1179703-17-3

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Biologische Aktivität

Beschreibung

Alle Adenosine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Analgesic agent‑4 (Compound 37) can bind to the human adenosine A₃ receptor, and this binding relies on conserved and enhanced hydrophobic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Analgesic agent-4 (3-300 mg/kg; subcutaneous injection; single administration) exhibits analgesic activity in the mouse writhing model induced by Acetic acid (HY-Y0319)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice treated Acetic acid (HY-Y0319)^[1]
Dosage:

3-300 mg/kg
Administration:

s.c.; single dose
Result:

Produced a 47% writhing inhibition rate at 100 mg/kg.
Inhibited writhing in a dose-dependent manner within the range of 30-300 mg/kg.

Chemical Information

CAS. Nr. 1179703-17-3
Molecular Weight 249.65
Formel C₁₁H₈ClN₃O₂
SMILES

OC(C=C1)=CC=C1NC(C2=CC=C(Cl)N=N2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mu Q, et al. Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vivo
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Analgesic agent-4

Alle Adenosine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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Analgesic agent-4 Related Classifications

HY-182782 Related Classifications