Antibacterial agent 128
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (HY-B0356) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL).
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- CAS. Nr.: 3059046-75-9
- Formel: C26H25FN4O9
- Molecular Weight:556.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
MIC: 0.25-64 μg/mL (P. aeruginosa), 1-32 μg/mL (B. pseudomallei), 4-128 μg/mL (B. thailandensis)[1]
In Vitro
Antibacterial agent 128 (compound 2d), bearing an hydroxypyridinone moiety with a cleavable linker, active on a large panel of strains of P. aeruginosa (MIC = 0.25-64 μg/mL), B. pseudomallei (MIC = 1-32 μg/mL) and B. thailandensis (MIC = 4-128 μg/mL). Moreover, Antibacterial agent 128 is active on the P. aeruginosa Ciprofloxacin-resistant strain AM85 without cytotoxicity[1].
Using iron transport systems is a promising strategy to bypass the bacteria cell membrane and restore the activity of conventional antibiotics such as Ciprofloxacin. The siderophore analogs correspond to a mono-catechol or a hydroxypyridinone moiety recognized by both Pseudomonas and Burkholderia species. Physico-chemical studies show that (i) conjugates were unable to interact or cross the membrane by passive diffusion and (ii) conjugates with cleavable linker are stable in physiologic environment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3059046-75-9
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Molecular Weight 556.50
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Formel C26H25FN4O9
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SMILES
CC(OC(N1CCN(CC1)C2=CC3=C(C(C(C(O)=O)=CN3C4CC4)=O)C=C2F)=O)OC(C5=CC(C(O)=CN5)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antibacterial agent 128 Related Classifications
HY-151944 Related Classifications
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