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Art. -Nr.: HY-184953

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Anticancer agent 345

Anticancer agent 345 is a heterobifunctional anticancer compound that exhibits weak antiproliferative activity against both ERα-overexpressing and non-overexpressing T-Rex 293 cells. Anticancer agent 345 can be used in cancer-related research.

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CAS. Nr.: 3099598-25-8
Formel: C₅₄H₅₇N₇O₃S
Molecular Weight:884.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 345 Chemical Structure

CAS. Nr.: 3099598-25-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

ERα

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

In Vitro

Anticancer agent 345 (III-154) exhibits moderate antiproliferative activity against MCF7 cells (GI₅₀ = 0.0-0.5 μM)^[1].
Anticancer agent 345 exhibits weak antiproliferative activity against both estrogen receptor α-overexpressing and non-overexpressing T-Rex 293 cells induced by Doxorubicin (HY-15142A) (GI₅₀ > 2.5 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3099598-25-8
Molecular Weight 884.14
Formel C₅₄H₅₇N₇O₃S
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(N4CCC(O)(CC4)CC5CCN(C6=CC=C([C@@H]7C8=CC=C(O)C=C8CC[C@@H]7C9=CC=CC=C9)C=C6)CC5)C=C3)=N[C@H](CC%10=NC=CO%10)C%11=NN=C(C)N2%11
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Eastman KJ, et al. Heterobifunctional compounds and their use in treating disease. WO2025189056 A1. WIPO. 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Anticancer agent 345

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