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Art. -Nr.: HY-187926

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Antimalarial agent 67

Antimalarial agent 67 is an orally active inositol acyltransferase Gwt1p inhibitor and antimalarial agent, with IC₅₀ values of 0.030 μM and 0.041 μM against P. falciparum 3D7 and K1 strains, respectively. Antimalarial agent 67 blocks inositol ring acylation by inhibiting the key enzyme Gwt1p in the GPI biosynthesis pathway of Plasmodium, thereby inhibiting parasite growth and maturation. Antimalarial agent 67 can be used for research on malaria.

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CAS. Nr.: 2675491-09-3
Formel: C₂₁H₁₉F₆N₇O₂
Molecular Weight:515.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 67 Chemical Structure

CAS. Nr.: 2675491-09-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Alle Acyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

Parasitic Infection

Antimalarial agent 67 (compound VII) (0.001-1 μg/mL; 72 h) exhibits antimalarial activity against the erythrocytic stages of P. falciparum 3D7 and K1 strains in vitro, with IC₅₀ values of 0.030 μM and 0.041 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

Antimalarial agent 67 (Compound VII) (10 mL/kg; p.o.; once daily; for 3 consecutive days) exhibits antimalarial activity in a humanized immunodeficient NSG mouse model engrafted with human erythrocytes and infected with P. falciparum (Pf3D70087/N9)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NSG (NOD-scid IL-2RYnull) mice (female) were infected with P. falciparum (Pf3D70087/N9)^[1]
Dosage:

10 mL/kg
Administration:

p.o.; once daily; for 3 consecutive days
Result:

Demonstrated in vivo antimalarial efficacy, being able to significantly reduce parasitemia in peripheral blood. The daily dose that reduced parasitemia by 90% compared to untreated control animals at day seven post-infection (ED90) was 6.2 mg/kg/day.

Chemical Information

CAS. Nr. 2675491-09-3
Molecular Weight 515.42
Formel C₂₁H₁₉F₆N₇O₂
SMILES

O=C(NCC1=CC=C(OCC(F)(F)F)C=C1)C=2C=C(C(=NC2N)N)N3N=C(N=C3)C4(CC4)C(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Takaaki Horii, et al. Novel antimalarial agent containing heterocyclic compound. WO2021149692A1. WIPO. 2021-07-29.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
- In Vivo
Chemical Information
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Antimalarial agent 67

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