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Art. -Nr.: HY-137475

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Chlorin e6 trimethyl ester

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT).

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Reinheit: 99.81%
CAS. Nr.: 35038-32-5
Formel: C₃₇H₄₂N₄O₆
Molecular Weight:638.75

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Chlorin e6 trimethyl ester Chemical Structure

CAS. Nr.: 35038-32-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
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Biologische Aktivität

Beschreibung

Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT)^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>100 μM Compound: chlorin-e6-trimethyl ester	Dark toxicity in human HepG2 cells after overnight incubation by MTT assay Dark toxicity in human HepG2 cells after overnight incubation by MTT assay	[PMID: 26306981]
HepG2	IC₅₀	26.5 μM Compound: chlorin-e6-trimethyl ester	Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay	[PMID: 26306981]

In Vivo

Chlorin e6 trimethyl ester (5 mg/kg; i.p.) has no tumorcidal activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 35038-32-5
Appearance Solid
Molecular Weight 638.75
Formel C₃₇H₄₂N₄O₆
Color Brown to black
SMILES

O=C(OC)C/C(C(NC(/C=C1C(CC)=C2C)=C3C)=C3C(OC)=O)=C(N=C(/C=C(C(C)=C/4C=C)\NC4=C/C2=N/1)[C@H]5C)\[C@H]5CCC(OC)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Research Square Preprint

2023 Jun 21.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 10 mg/mL (15.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5656 mL

7.8278 mL

15.6556 mL

5 mM

0.3131 mL

1.5656 mL

3.1311 mL

10 mM

0.1566 mL

0.7828 mL

1.5656 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pandey RK, et, al. Chlorin and porphyrin derivatives as potential photosensitizers in photodynamic therapy. Photochemistry and Photobiology. 1991. 53(1):65-72.

[2]. Bauer D, et, al. Functionalization of chlorin e6 trimethylester towards potential amphiphilic photosensitizers for photodynamic therapy. Journal of Porphyrins and Phthalocyanines. 2019. 23(3): 243-250.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5656 mL	7.8278 mL	15.6556 mL	39.1389 mL
	5 mM	0.3131 mL	1.5656 mL	3.1311 mL	7.8278 mL
	10 mM	0.1566 mL	0.7828 mL	1.5656 mL	3.9139 mL
	15 mM	0.1044 mL	0.5219 mL	1.0437 mL	2.6093 mL

Keywords

Chlorin e6 trimethyl ester

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo Dissolution Calculator
Reinheit & Dokumentation
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Chlorin e6 trimethyl ester

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Publications Citing Use of MedChemExpress (MCE) Chlorin e6 trimethyl ester

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Chlorin e6 trimethyl ester

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Macrocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Chlorin e6 trimethyl ester

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Chlorin e6 trimethyl ester Related Classifications

Art. -Nr.: HY-137475