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Art. -Nr.: HY-114322A

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cis-VZ185

cis-VZ185 serves as a non-degradative control and inactive analog of VZ185 (HY-114322), a dual-target BRD7/BRD9 degrader PROTAC. cis-VZ185 exerts antiproliferative activity against epithelioid sarcoma cells only at high concentrations. cis-VZ185 induces morphological changes in osteosarcoma cells. cis-VZ185 can be used in studies related to epithelioid sarcoma.
(Pink: BRD9 and BRD7 ligand (HY-111905A); Blue: VHL ligand (HY-176302); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2306193-98-4
Formel: C₅₃H₆₇FN₈O₈S
Molecular Weight:995.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

cis-VZ185 Chemical Structure

CAS. Nr.: 2306193-98-4

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Biologische Aktivität

Beschreibung

cis-VZ185 serves as a non-degradative control and inactive analog of VZ185 (HY-114322), a dual-target BRD7/BRD9 degrader PROTAC. cis-VZ185 exerts antiproliferative activity against epithelioid sarcoma cells only at high concentrations. cis-VZ185 induces morphological changes in osteosarcoma cells. cis-VZ185 can be used in studies related to epithelioid sarcoma^[1]. (Pink: BRD9 and BRD7 ligand (HY-111905A); Blue: VHL ligand (HY-176302); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

cis-VZ185 (10 μM; 20 h) induces significant morphological changes in U2OS cells, with an induction rate of 80%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2306193-98-4
Molecular Weight 995.21
Formel C₅₃H₆₇FN₈O₈S
SMILES

CN1C=C(C2=CC=NC=C2C1=O)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@@H](O)C6)=O)C=CC(C8=C(N=CS8)C)=C5)CC4)C(OC)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rasmussen SV, et al. Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology. Clinical and translational medicine. 2022 Jul;12(7):e961. [Content Brief]

[2]. Jiang M, et al. LIN28-Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs. ChemMedChem. 2025 Jan 02;20(1):e202400547. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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cis-VZ185

High-Throughput Bioactive Compound Library

Alle PROTACs Isoform-spezifische Produkte anzeigen

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cis-VZ185 Related Classifications

HY-114322A Related Classifications