cPP12-2-Lys
cPP12-2-Lys is a cyclic cell-penetrating peptide that serves as a negative control, i.e., it lacks any NatD bisubstrate moiety. cPP12-2-Lys is not a NatD inhibitor (IC50 = 9500 nM), but it possesses excellent cell-penetrating ability and can mediate the entry of conjugated bisubstrate inhibitors into non-small cell lung cancer (NSCLC) cells. cPP12-2-Lys can be used in NSCLC research.
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- Formel: C64H95N23O10S
- Molecular Weight:1378.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
cPP12-2-Lys (0.15 nM-30 μM; 30 min) alone shows very weak inhibitory activity against purified NatD enzyme with an IC50 of 9500 nM[1].
cPP12-2-Lys (5 μM; 2 h) is taken up by A549 non-small cell lung cancer cells, but at lower levels than its bisubstrate inhibitor-conjugated counterpart[1].
cPP12-2-Lys (up to 10 μM; 48 h) does not reduce viability of A549 and H1299 non-small cell lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1378.65
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Formel C64H95N23O10S
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Sequence
Cyclo(Phe-d{Phe}-{Bta}-Arg-d{Arg}-Arg-d{Arg}-Gln)-Lys
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Sequence Shortening
Cyclo(F-d{Phe}-{Bta}-R-d{Arg}-R-d{Arg}-Q)-K
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
cPP12-2-Lys Related Classifications
HY-P11856 Related Classifications
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