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Art. -Nr.: HY-P99836

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Biologically Validated

Cudarolimab

Name: Cudarolimab
Brand: MedChemExpress
SKU: HY-P99836
Price: 350.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: IBI101)

Kundenbewertung

Based on 1 Customer Validation

Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 95.00%
CAS. Nr.: 2244739-29-3
Molecular Weight:145.94 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cudarolimab Chemical Structure

CAS. Nr.: 2244739-29-3

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Preis

Verfügbarkeit

Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

TNFRSF4/OX40/CD134

Alle Orexin Receptor (OX Receptor) Isoform-spezifische Produkte anzeigen :

In Vitro

Cudarolimab (0.01, 1, 100 or 10000 nM) binds to OX40 and partially blocks the binding of OX40 to its ligand OX40L in CHO-S cells overexpressing human OX40 (CHO-S-hOX40). Cudarolimab activates OX40 dependent NF-κB reporters with an EC₅₀ value of 4.432 nM in Jurkat-OX40 reporter cells co-cultured with Raji cells^[1].
Cudarolimab (0.01, 0.1, 1, 10, 100 or 1000 nM) binds to activated human CD4⁺ T cells and activated cynomolgus monkey CD4⁺ T cells in a dose dependent manner^[1].
Cudarolimab (0.4, 4.0 and 40.4 nM) increases IL-2 secretion with dose dependent manner in human CD4⁺ T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cudarolimab (10 mg/kg; i.p.; single dose on days 3, 7, 11, 14 and 15) significantly reduces tumor volume in humanized NOG mice bearing LoVo tumors^[1].
Cudarolimab (0.1, 1 and 10 mg/kg; i.p.; single dose on days 6, 9, 12 and 16) significantly reduces tumor volume, increases IFN-γ⁺ and IFN-α⁺ expression in CD8⁺ T cells in tumor and spleen of human OX40 knock-in mice bearing MC38 tumors^[1].
Cudarolimab (10 mg/kg; i.p.; single dose on days 10 and 14) significantly reduces the expression of CD3⁺CD8⁺, CD3⁺CD4⁺, CD4⁺CD25^highFoxP3⁺ in the tumor and spleen of human OX40 knock-in mice bearing MC38 tumors^[1].
Pharmacokinetic (PK) parameters of Cudarolimab in cynomolgus macaques^[1]

Dose (mg/kg)	C_max (µg/mL )	T_max (h)	AUC_0-∞ (h•µg/mL )	T_1/2 (h)	Cl (mL/h/kg)	MRT_last (h)
0.1	3.07±0.40	0.08±0.00	347.98±99.30	162.98±103.01	0.31±0.08	186.34±110.68
0.5	9.78±3.27	0.40±0.78	1429.19±607.21	129.47±114.44	0.40±0.14	136.03±108.05
2.5	63.10±15.29	0.08±0.00	10304.06±3403.59	190.89±92.94	0.27±0.09	212.29±114.61
12.5	296.57±58.05	0.40±0.78	33511.65±14982.36	120.30±153.26	0.44±0.20	114.93±87.66

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Humanized NOG mice bearing LoVo tumors^[1].
Dosage:

10 mg/kg.
Administration:

Intraperitoneal injection; single dose on days 3, 7, 11, 14 and 15.
Result:

Reduced tumor volume.

Animal Model:

Human OX40 knock-in mice bearing MC38 tumors^[1].
Dosage:

0.1, 1 and 10 mg/kg.
Administration:

Intraperitoneal injection; single dose on days 6, 9, 10, 12, 14 and 16.
Result:

Showed anti-tumor activity.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

7293 [NCBI]

Accession

P43489

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Flow cytometric analysis of 1X10⁶ 500 ng/mL anti-CD3 and 500 ng/mL ant-CD28 co-stimulated Jurkat cells(24h) with Cudarolimab (HY-P99836, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

Chemical Information

CAS. Nr. 2244739-29-3
Appearance Liquid
Molecular Weight 145.94 kDa
Color Colorless to light yellow
SMILES

[Cudarolimab]
Synonyms

IBI101
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Kuang Z, et al. Development and characterization of a novel anti-OX40 antibody for potent immune activation. Cancer Immunol Immunother. 2020 Jun;69(6):939-950. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

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Human IgG1 kappa
1/16

Flow cytometric analysis of 1X10⁶ 500 ng/mL anti-CD3 and 500 ng/mL ant-CD28 co-stimulated Jurkat cells(24h) with Cudarolimab (HY-P99836, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
1/16

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Cudarolimab

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Alle Orexin Receptor (OX Receptor) Isoform-spezifische Produkte anzeigen