Cyclotraxin B
Based on 3 publication(s) in Google Scholar
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.78%
- CAS. Nr.: 1203586-72-4
- Formel: C48H73N13O17S3
- Molecular Weight:1200.37
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Speicherung:
Stored under nitrogen, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cyclotraxin B
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Biologische Aktivität
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TrkB |
Cyclotraxin B (1 pM-100 nM; 48 h) inhibits BDNF-induced neurite outgrowth in a dose-dependent manner with an IC50 of 12.9 pM, and significantly reduces the phosphorylation level of BDNF-induced MAPK in nnr5 PC12-TrkB cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cyclotraxin B (intraperitoneal injection; 2×20 mg/kg; two times; with a 90-minute interval) can prevent and reverse cold allodynia induced by BDNF or infraorbital nerve ligation in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult Swiss mice (20-25 g)[1]
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Dosage:2×200 μg (Cyclotraxin B was in the fusion form with the HIV tat protein)
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Administration:Intravenous injection; two times with a 90-minute interval
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Result:Dramatically decreased the total level of TrkB phosphorylation in the mouse brain.
Does not possess any antidepressant-like properties when injected acutely.
Significantly increased the time mice spent in the central area during the open field test.
Significantly increased the number of entries and the time spent in open arms by mice during the elevated-plus maze.
Chemical Information
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CAS. Nr. 1203586-72-4
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Appearance Solid
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Molecular Weight 1200.37
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Formel C48H73N13O17S3
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Color White to off-white
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Sequence
Cys-Asn-Pro-Met-Gly-Tyr-Thr-Lys-Glu-Gly-Cys (Disulfide bridge:Cys1-Cys11)
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Sequence Shortening
CNPMGYTKEGC (Disulfide bridge:Cys1-Cys11)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Stored under nitrogen, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels. [Abstract]2022 Jan;179(2):301-321. PMID: 34622942 -
J Mol Neurosci
2022 Dec;72(12):2497-2506. PMID: 36527597 -
Genes Brain Behav
Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain. [Abstract]2023 Apr;22(2):e12842. PMID: 36889983
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (83.31 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (83.31 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. [Content Brief]
[2]. Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. [Content Brief]
[3]. Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8331 mL | 4.1654 mL | 8.3308 mL | 20.8269 mL |
| 5 mM | 0.1666 mL | 0.8331 mL | 1.6662 mL | 4.1654 mL | |
| 10 mM | 0.0833 mL | 0.4165 mL | 0.8331 mL | 2.0827 mL | |
| 15 mM | 0.0555 mL | 0.2777 mL | 0.5554 mL | 1.3885 mL | |
| 20 mM | 0.0417 mL | 0.2083 mL | 0.4165 mL | 1.0413 mL | |
| 25 mM | 0.0333 mL | 0.1666 mL | 0.3332 mL | 0.8331 mL | |
| 30 mM | 0.0278 mL | 0.1388 mL | 0.2777 mL | 0.6942 mL | |
| 40 mM | 0.0208 mL | 0.1041 mL | 0.2083 mL | 0.5207 mL | |
| 50 mM | 0.0167 mL | 0.0833 mL | 0.1666 mL | 0.4165 mL | |
| 60 mM | 0.0139 mL | 0.0694 mL | 0.1388 mL | 0.3471 mL | |
| 80 mM | 0.0104 mL | 0.0521 mL | 0.1041 mL | 0.2603 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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