DCE_42
DCE_42 is a potent EZH2 inhibitor with an IC50 value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 669749-45-5
- Formel: C22H19N9O2S
- Molecular Weight:473.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
EZH2 22.6 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| DB | IC50 |
32.8 μM
Compound: DCE_42
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Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay
Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay
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[PMID: 27289323] |
| Toledo | IC50 |
24.1 μM
Compound: DCE_42
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Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay
Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay
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[PMID: 27289323] |
In Vitro
DCE_42 inhibits Toledo and DB cell proliferation with IC50 values of 24.1, 32.8 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS. Nr. 669749-45-5
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Molecular Weight 473.51
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Formel C22H19N9O2S
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SMILES
O=C1NC(NC2=NC(C)=C3C=C(C=CC3=N2)OC)=NC(CSC4=NN=NN4C5=CC=CC=C5)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DCE_42 Related Classifications
HY-122115 Related Classifications
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