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Art. -Nr.: HY-152247

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DDO3711

DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC₅₀ =164.1 nM) not ASK2 (IC₅₀>20 μM). DDO3711 significantly dephosphorylates p-ASK1^T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research.

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CAS. Nr.: 2673364-10-6
Formel: C₄₂H₄₁N₉O₆
Molecular Weight:767.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DDO3711 Chemical Structure

CAS. Nr.: 2673364-10-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

MAP3K6/ASK2

>20 μM (IC₅₀)

Alle MAP3K Isoform-spezifische Produkte anzeigen :

In Vitro

DDO3711 (15 μM; 24 h) shows antiproliferation effects on gastric cancer cells by reducing p-ASK1^T838 in a PP5-dependent manner. DDO3711 does not inhibit the proliferation of GES-1 cells and HGC-27 cells^[1].
DDO3711 (5 μM; 1-24 h) inhibited the expression of CDK4/6 and cyclin D1 in a concentration-dependent manner^[1].
DDO3711 (5-50 μM; 0.5-2 h) potently dephosphorylates p-ASK1^T838 both in vitro and in cells. DDO3711 concentration-dependently reduced the level of p-JNK and p-p38^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MKN45 cells
Concentration:

15 μM
Incubation Time:

24 h
Result:

Showed strong antiproliferative activity (IC₅₀=0.5 μM).

Cell Cycle Analysis^[1]

Cell Line:

MKN45 cells
Concentration:

5 μM
Incubation Time:

1-24 h
Result:

Inhibited the expression of CDK4/6 and cyclin D1 in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MKN45 cells
Concentration:

5, 25, 50 μM
Incubation Time:

0.5-2 h
Result:

Could dephosphorylate p-ASK1^T838 in a time- and concentration-dependent manner in vitro.

In Vivo

DDO3711 (20, 40 mg/kg; IP; daily; for 21 days) causes significant inhibition of tumor growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Four-week-old BALB/c nude mice with MKN45 cells^[1]
Dosage:

20, 40 mg/kg
Administration:

IP; daily; for 21 days
Result:

Caused significant inhibition of tumor growth in a dose-dependent manner.
Significantly decreased the level of p-ASK1^T838.

Chemical Information

CAS. Nr. 2673364-10-6
Molecular Weight 767.83
Formel C₄₂H₄₁N₉O₆
SMILES

COC1=CC=C(C=C1OC)C2=NC(CC3=CC=C(C=C3)C(NCCCCCCNC(C4=CC=C(C=C4)C(NC5=CN6C=C(C=CC6=N5)N7C=CN=C7)=O)=O)=O)=NO2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qiuyue Zhang, et al. Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity. J Am Chem Soc. 2022 Dec 22. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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DDO3711

Alle MAP3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DDO3711 Related Classifications

HY-152247 Related Classifications