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Art. -Nr.: HY-115929

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DENV-IN-4

DENV-IN-4 is a potent DENV inhibitor (DENV EC₅₀=4.79 μM, Vero CC₅₀>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect.

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CAS. Nr.: 2762302-75-8
Formel: C₂₈H₃₂N₄O₄Si
Molecular Weight:516.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

DENV-IN-4 Chemical Structure

CAS. Nr.: 2762302-75-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RNA Polymerase

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In Vitro

DENV-IN-4 (compound 15) (0.064-200 μM; 3 days) has antiviral effect and not related to its toxicity (DENV EC₅₀=4.79 μM, Vero CC₅₀>100, SI>20.9)^[1].
DENV-IN-4 (3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7; 48 hours) inhibits the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero^[1].
DENV-IN-4 (7.5 and 15 μM; 48 hours) can effectively inhibit DENV infection in Vero cells, and completely inhibited at 15 μM^[1].
DENV-IN-4 (0-15 μM; 48 hours) inhibits DENV2 E protein production with good concentration-dependent relationship in Vero cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:

Vero^[1]
Concentration:

0.064-200 μM
Incubation Time:

3 days
Result:

Showed antiviral effect of DENV-IN-4 was not related to its toxicity (Vero EC₅₀=4.79 μM, CC₅₀>100, SI>20.9).

RT-PCR

Cell Line:

Vero, A549 and Huh-7 cells^[1]
Concentration:

3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7
Incubation Time:

48 hours
Result:

Inhibited the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero.

Western Blot Analysis

Cell Line:

Vero^[1]
Concentration:

7.5 and 15 μM
Incubation Time:

48 hours
Result:

Effectively inhibited DENV infection and completely inhibited at 15 μM.

Immunofluorescence

Cell Line:

Vero^[1]
Concentration:

0-15 μM
Incubation Time:

48 hours
Result:

Inhibited DENV2 E protein production with good concentration-dependent relationship.

Chemical Information

CAS. Nr. 2762302-75-8
Molecular Weight 516.66
Formel C₂₈H₃₂N₄O₄Si
SMILES

O=C1[C@@](CC2=CC=CC=C23)([H])N3[C@](C4=CC=C(C=C4)O[Si](C)(C)C(C)(C)C)([H])N1NC5=CC=C(C=C5)[N+]([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qian W, et al. Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection [published online ahead of print, 2022 Jan 24]. Bioorg Chem. 2022;120:105639. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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DENV-IN-4

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DENV-IN-4 Related Classifications

HY-115929 Related Classifications