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Art. -Nr.: HY-187674

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Dicranin

Dicranin is a 15-lipoxygenase (15-LOX) inhibitor and bacterial agent. Dicranin inhibits the dioxygenation reaction of polyenoic fatty acids by irreversibly binding to lipoxygenase. Dicranin can be isolated from the phospholipids of Philonotis fontana, Leptodontium paradoxum, and Dicranum scoparium. Dicranin can be used in studies related to Gram-positive bacterial infections.

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CAS. Nr.: 61481-30-9
Formel: C₁₈H₂₆O₂
Molecular Weight:274.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Dicranin Chemical Structure

CAS. Nr.: 61481-30-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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^[1]

15-LOX

Alle Lipoxygenase Isoform-spezifische Produkte anzeigen :

In Vitro

OthersBacterial Infection

Others

Dicranin (0.36-3.6 μM) potently inhibits soybean 15-lipoxygenase, achieving 100% inhibition at 3.6 μM and 37% inhibition at 0.36 μM^[2].

Bacterial Infection

Dicranin (10-1000 μg/disc) inhibits growth of Gram-positive bacteria (Bacillus stearothermophilus, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis) in disc diffusion assays, with the strongest activity against Streptococcus faecalis (inhibition down to 10 μg/disc), and no activity against tested Gram-negative bacteria at 1000 μg/disc^[2].
Dicranin (10-200 μg/mL; up to 24 h) acts as a bactericide against Bacillus cereus (down to 150 μg/mL) and Bacillus stearothermophilus (at 200 μg/mL), with time-dependent bactericidal/bacteriostatic effects at intermediate concentrations, weak growth inhibition against Bacillus stearothermophilus at 10 μg/mL, no activity against Bacillus cereus at 10 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gram Staining of Tissue Sections

Chemical Information

CAS. Nr. 61481-30-9
Molecular Weight 274.40
Formel C₁₈H₂₆O₂
SMILES

CC/C=C\C/C=C\C/C=C\CC#CCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Roy Chowdhuri S, et al. "Dicranin" in the Membrane Phospholipids of a Dicranaceae and Pottiaceae Moss Member of the Eastern Himalayan Biodiversity Hotspot. Lipids. 2018 May;53(5):539-545.

[2]. Borel C, et al. Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium. Journal of natural products. 1993 Jul;56(7):1071-7.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Dicranin

Alle Lipoxygenase Isoform-spezifische Produkte anzeigen

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IC50 & Target

In Vitro

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Dicranin Related Classifications

HY-187674 Related Classifications

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