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Art. -Nr.: HY-100714D

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DL-AP5 lithium

(Synonyms: 2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina.

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CAS. Nr.: 125229-62-1
Formel: C₅H₁₁LiNO₅P
Molecular Weight:203.06

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DL-AP5 lithium Chemical Structure

CAS. Nr.: 125229-62-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

NMDA Receptor

Alle iGluR Isoform-spezifische Produkte anzeigen :

In Vitro

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels^[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA^[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption^[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (180-230 g)^[3]
Dosage:

1, 3.2 and 10 μg/rat
Administration:

Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:

Significantly decreased the effect of NMDA (10^-2 μg/rat, intra-CA1) with significant interaction.

Animal Model:

Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:

0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:

Intracerebroventricular injection
Result:

Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.

Animal Model:

Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:

5 nmol
Administration:

Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:

Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.

Chemical Information

CAS. Nr. 125229-62-1
Molecular Weight 203.06
Formel C₅H₁₁LiNO₅P
SMILES

NC(CCCP(O)(O)=O)C(O[Li])=O
Synonyms

2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All In Vivo Efficacy StudyBio/Physico-chemical Assay

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Journal Impact Factor

Neuron

Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]

2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265
Int J Biol Macromol

SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. [Abstract]

2024 Oct 28:136767. PMID: 39476923

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2^fl/fl and Setd2-cKO mice.
bioRxiv

2025 July 07.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]

[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]

[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]

[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]

[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DL-AP5 lithium

3 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise

1/16
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Customer Validation
Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Customer Validation
The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2^fl/fl and Setd2-cKO mice.

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DL-AP5 lithium

Publications Citing Use of MedChemExpress (MCE) DL-AP5 lithium

Alle iGluR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DL-AP5 lithium Related Classifications

HY-100714D Related Classifications