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Art. -Nr.: HY-128890B

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DOTA-NHS-ester TFA

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DOTA-NHS-ester (TFA) is used as a linker for affibody molecules, and it can be employed in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. DOTA-NHS-ester can be used to label radiotracers or imaging probes for tumor detection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 95.0%
Formel: C₂₂H₃₂F₃N₅O₁₂
Molecular Weight:615.51

Speicherung:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DOTA-NHS-ester TFA Chemical Structure

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Publications Citing Use of MedChemExpress (MCE) DOTA-NHS-ester TFA

Adv Nanobiomed Res. 2023 Sep 3.

Customer Validation & Images

In Vivo Efficacy Study

In Vivo Efficacy Study
In Vivo Efficacy Study

Biologische Aktivität
- Beschreibung
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle ADC Linkers Isoform-spezifische Produkte anzeigen :

Chemical Information

Appearance Solid
Molecular Weight 615.51
Formel C₂₂H₃₂F₃N₅O₁₂
Color White to off-white
SMILES

OC(C(F)(F)F)=O.O=C(ON1C(CCC1=O)=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

All In Vivo Efficacy Study

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Journal Impact Factor

Adv Nanobiomed Res

2023 Sep 3.

DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with ⁶⁴Cu (OAc)₂ at 50 ℃ for 1 h to obtain the ⁶⁴Cu-labelled PSP. PSP@Ab@PEG exhibited increased blood circulation in BALB/c mice with blood clearance half-life periods found to be 12 min.

DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with ⁶⁴Cu (OAc)₂ at 50 ℃ for 1 h to obtain the ⁶⁴Cu-labelled PSP. More PSP–NH2 accumulated in the liver site while a lot more PSP@Ab@PEG accumulated in the spleen.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (203.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6247 mL

8.1233 mL

16.2467 mL

5 mM

0.3249 mL

1.6247 mL

3.2493 mL

10 mM

0.1625 mL

0.8123 mL

1.6247 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hoppmann S, et al. Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting. Bioconjug Chem. 2011 Mar 16;22(3):413-21. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6247 mL	8.1233 mL	16.2467 mL	40.6167 mL
	5 mM	0.3249 mL	1.6247 mL	3.2493 mL	8.1233 mL
	10 mM	0.1625 mL	0.8123 mL	1.6247 mL	4.0617 mL
	15 mM	0.1083 mL	0.5416 mL	1.0831 mL	2.7078 mL
	20 mM	0.0812 mL	0.4062 mL	0.8123 mL	2.0308 mL
	25 mM	0.0650 mL	0.3249 mL	0.6499 mL	1.6247 mL
	30 mM	0.0542 mL	0.2708 mL	0.5416 mL	1.3539 mL
	40 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0154 mL
	50 mM	0.0325 mL	0.1625 mL	0.3249 mL	0.8123 mL
	60 mM	0.0271 mL	0.1354 mL	0.2708 mL	0.6769 mL
	80 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.5077 mL
	100 mM	0.0162 mL	0.0812 mL	0.1625 mL	0.4062 mL

Keywords

DOTA-NHS-ester TFA

1 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

1/16
1/16

DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

Customer Validation
PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with ⁶⁴Cu (OAc)₂ at 50 ℃ for 1 h to obtain the ⁶⁴Cu-labelled PSP. PSP@Ab@PEG exhibited increased blood circulation in BALB/c mice with blood clearance half-life periods found to be 12 min.
1/16

DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

Customer Validation
PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with ⁶⁴Cu (OAc)₂ at 50 ℃ for 1 h to obtain the ⁶⁴Cu-labelled PSP. More PSP–NH2 accumulated in the liver site while a lot more PSP@Ab@PEG accumulated in the spleen.

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DOTA-​NHS-ester TFA

Publications Citing Use of MedChemExpress (MCE) DOTA-​NHS-ester TFA

Alle ADC Linkers Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table