DQ661
DQ661 is a potent PPT1 inhibitor. DQ661 is a dimeric quinacrine autophagy inhibitor. DQ661 inhibits mTORC1 activity. DQ661 decreases the protein expression of pS6K T389, pS6 S240-244. DQ661 shows anticancer activity.
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- CAS. Nr.: 2027551-01-3
- Formel: C41H47Cl2N5O2
- Molecular Weight:712.75
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 2027551-01-3
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Molecular Weight 712.75
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Formel C41H47Cl2N5O2
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SMILES
ClC(C=CC1=C2NCCCCCCN(CCCCCCNC3=C4C=CC(Cl)=CC4=NC5=C3C=C(OC)C=C5)C)=CC1=NC6=C2C=C(OC)C=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Nicastri MC, et al. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol. 2017 Nov 30;5(1):e1395504. [Content Brief]
[2]. Rebecca VW, et al. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 Nov;7(11):1266-1283. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DQ661 Related Classifications
HY-170670 Related Classifications
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