DS17701585
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC50 values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and SOX2. DS17701585 can be used for cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2983027-66-1
- Formel: C24H26N4O5S
- Molecular Weight:482.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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H3K27 0.45 μM (IC50) |
SOX2 0.70 μM (IC50) |
EP300 0.04 μM (IC50) |
CBP 0.15 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LK-2 | IC50 |
0.7 μM
Compound: 11; DS17701585
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Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
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[PMID: 35413416] |
Chemical Information
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CAS. Nr. 2983027-66-1
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Molecular Weight 482.55
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Formel C24H26N4O5S
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SMILES
O=C([C@@H](C1)N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)CS1(=O)=O)NC4=CC=CC5=C4C=NN5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DS17701585 Related Classifications
HY-143443 Related Classifications
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