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Art. -Nr.: HY-14815

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Fosbretabulin

(Synonyms: Combretastatin A4 phosphate)

Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors.

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CAS. Nr.: 222030-63-9
Formel: C₁₈H₂₁O₈P
Molecular Weight:396.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Fosbretabulin Chemical Structure

CAS. Nr.: 222030-63-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A10	EC₅₀	7 nM Compound: CA4P	Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique	[PMID: 20973488]
DU-145	GI₅₀	0.00336 μM Compound: CA4P	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28217276]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay	[PMID: 27592394]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27597243]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay	10.1039/C6MD00360E
HCT-116	IC₅₀	0.042 μM Compound: CA-4P	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
HeLa	IC₅₀	4.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells by sulforhodamine B assay Antiproliferative activity against human HeLa cells by sulforhodamine B assay	[PMID: 20973488]
HeLa	IC₅₀	5.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay	[PMID: 20973488]
MGC-803	IC₅₀	0.02 μM Compound: CA-4P	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
NCI-H460	GI₅₀	0.00282 μM Compound: CA4P	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28217276]
PC-3	IC₅₀	0.033 μM Compound: CA-4P	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
SK-OV-3	GI₅₀	0.0019 μM Compound: CA4P	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 28217276]
SK-OV-3	IC₅₀	4.5 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay	[PMID: 20973488]
SK-OV-3	IC₅₀	6.6 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay	[PMID: 20973488]

Chemical Information

CAS. Nr. 222030-63-9
Molecular Weight 396.33
Formel C₁₈H₂₁O₈P
SMILES

O=P(O)(O)OC1=C(C=CC(/C=C\C2=CC(OC)=C(C(OC)=C2)OC)=C1)OC
Synonyms

Combretastatin A4 phosphate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mooney, et al. "A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome." Thyroid 19.3 (2009): 233-240. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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