GCS-12–6
GCS-12-6 is a potent Th2-selective NKT cell agonist targeting the CD1d protein. GCS-12-6 mediates the rapid presentation of glycolipid/CD1d complexes on the surface of antigen-presenting cells. GCS-12-6 holds promise for research on autoimmune diseases (such as inflammatory bowel disease and multiple sclerosis).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C42H84N2O11S
- Molecular Weight:825.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
CD1d |
IL-4 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse splenocytes
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Concentration:10, 100, 1000 nM
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Incubation Time:72 h
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Result:Did not exhibit apparent cytotoxicity at any of the tested concentrations, and the cell viability remained at a very high level.
In Vivo
GCS-12-6 (1 μg; i.p.; administered on days 2 and 4 of the experiment, twice in total; observation until day 8) significantly alleviates colonic inflammation, reduces the disease activity index, protects colonic length, and prevents body weight loss in the DSS (HY-116282C)-induced C57BL/6 mouse colitis model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6-8 weeks old)[2]
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Dosage:1 μg
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Administration:i.p.; on days 2 and 4; 8 days
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Result:Alleviated the body weight loss induced by DSS and significantly reduced the disease activity index (DAI) scores.
Dissection showed that colon shortening was significantly protected, and histopathological (H&E staining) results indicated that it could effectively alleviate the destruction of intestinal crypts and the infiltration of inflammatory cells.
Chemical Information
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Molecular Weight 825.19
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Formel C42H84N2O11S
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SMILES
O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GCS-12–6 Related Classifications
HY-175365 Related Classifications
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