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DYNLL2 - dynein light chain LC8-type 2 Gene

Also Known as Dlc2; DNCL1B; RSPH22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140735

About DYNLL2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,083,419-58,095,542 (from NCBI)

This gene has 1 transcript (splice variant), 252 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues.

Summary

Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

DYNLL2 Products (1)

mRNA	Protein	Name
NM_080677.3	NP_542408.1	dynein light chain 2, cytoplasmic

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in 9+0 non-motile cilium	IDA IDA: Inferred from direct assay	29257953	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	20921139	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22328512	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22328512	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	22328512	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	22328512	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLL2 Protein Structure

Dynein_light

0
89 a.a.

Protein Preferred Names	Protein Names
dynein light chain 2, cytoplasmic	8 kDa dynein light chain b

DYNLL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DYNLL2	Q96FJ2	REDIC1	Homo sapiens	Q86WS4	Validated Y2H	25416956
Intra	DYNLL2	Q96FJ2	REDIC1	Homo sapiens	Q86WS4	Y2H Array	25416956
Intra	DYNLL2	Q96FJ2	RASGRP3	Homo sapiens	Q8IV61	Y2H Prey Pooling	25416956
Intra	DYNLL2	Q96FJ2	PKIG	Homo sapiens	Q9Y2B9	Validated Y2H	32296183
Intra	DYNLL2	Q96FJ2	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	DYNLL2	Q96FJ2	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	35271311
Intra	DYNLL2	Q96FJ2	SECISBP2L	Homo sapiens	Q93073	Validated Y2H	25416956
Intra	DYNLL2	Q96FJ2	SECISBP2L	Homo sapiens	Q93073	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	DYNC1I1	Homo sapiens	O14576	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	35271311
Intra	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Y2H Prey Pooling	32296183
Intra	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32296183
Intra	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	TAP	27173435
Intra	DYNLL2	Q96FJ2	BMF	Homo sapiens	Q96LC9	Y2H Prey Pooling	25416956
Intra	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	TAP	27173435
Intra	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Anti Tag CoIP	35271311
Intra	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Y2H Pooling	16189514
Intra	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Y2H Array	31515488
Intra	DYNLL2	Q96FJ2	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Y2H Prey Pooling	32296183
Intra	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
Intra	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Y2H Array	32296183
Intra	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	35271311
Intra	DYNLL2	Q96FJ2	DNAL4	Homo sapiens	O96015	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	DNAL4	Homo sapiens	O96015	Y2H Array	31515488
Intra	DYNLL2	Q96FJ2	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	DYNLL2	Q96FJ2	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	DYNLL2	Q96FJ2	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	33961781
Intra	DYNLL2	Q96FJ2	MORN3	Homo sapiens	Q6PF18	Validated Y2H	25416956
Cross	DYNLL2	Q96FJ2	rex_htlv2	Human T-cell leukemia virus	Q85601	MAPPIT	22458338
Cross	DYNLL2	Q96FJ2	rex_htl1c	Human T-cell leukemia virus 1	P0C206	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

DYNLL2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P811062	DYNLL2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly	SRTD11
Bardet-Biedl Syndrome 7	BBS7 Bardet-Biedl Syndrome, Type 7
Louping Ill
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04089	DYNLL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DYNLL2	VGNC	VGNC:98902
Mus musculus	DYNLL2	MGD	MGI:1915347
Rattus norvegicus	DYNLL2	RGD	RGD:619860
Canis familiaris	DYNLL2	VGNC	VGNC:40151
Bos taurus	DYNLL2	VGNC	VGNC:28275
Others	DYNLL2	NCBI