E2F1 - E2F transcription factor 1 Gene

Also Known as RBP3; E2F-1; RBAP1; RBBP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1869

About E2F1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,675,477-33,686,385 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 12.7), testis (RPKM 5.6) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent Apoptosis. [provided by RefSeq, Jul 2008]

E2F1 Products (1)

mRNA	Protein	Name
NM_005225.3	NP_005216.1	transcription factor E2F1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15073182	GOA
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11418595	GOA
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	17062573	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15731768	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20040599	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16360038	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15735762	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	16360038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7784053	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12717439	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12717439	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	15766563	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	20176812	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20176812	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20224733	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21454377	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15565177	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15565177	GOA
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	20224733	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	15766563	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28992046	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20040599	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1531329	GOA
acts upstream of regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20224733	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	16360038	GOA
part of Rb-E2F complex	IDA IDA: Inferred from direct assay	20224733	GOA
part of Rb-E2F complex	IPI IPI: Inferred from physical interaction	16360038	GOA
located in chromatin	IDA IDA: Inferred from direct assay	21454377	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28992046	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1531329	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23629655	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F1 Protein Structure

E2F_TDP

0
100
200
300
400
437 a.a.

Protein Preferred Names	Protein Names
transcription factor E2F1	PBR3

E2F1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	E2F1	Q01094	STAT1	Homo sapiens	P42224	Display Tech	20195357
Intra	E2F1	Q01094	MCPH1	Homo sapiens	Q8NEM0	BiFC	18660752
Intra	E2F1	Q01094	MCPH1	Homo sapiens	Q8NEM0	Anti Bait CoIP	18660752
Cross	E2F1	Q01094	Sirt1	Mus musculus	Q923E4	Anti Tag CoIP	16892051
Cross	E2F1	Q01094	Sirt1	Mus musculus	Q923E4	Anti Bait CoIP	16892051
Intra	E2F1	Q01094	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	16892051
Intra	E2F1	Q01094	L3MBTL3	Homo sapiens	Q96JM7	Anti Tag CoIP	17517653
Intra	E2F1	Q01094	SP1	Homo sapiens	P08047	Pull Down	8657141
Intra	E2F1	Q01094	TOPBP1	Homo sapiens	Q92547	Anti Tag CoIP	17006541
Intra	E2F1	Q01094	PRMT5	Homo sapiens	O14744	Anti Bait CoIP	22327218
Intra	E2F1	Q01094	PRMT5	Homo sapiens	O14744	Pull Down	22327218
Intra	E2F1	Q01094	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	22327218
Intra	E2F1	Q01094	RRP1B	Homo sapiens	Q14684	Anti Bait CoIP	20040599
Intra	E2F1	Q01094	CDK8	Homo sapiens	P49336	Anti Bait CoIP	18794899
Intra	E2F1	Q01094	KAT2A	Homo sapiens	Q92830	Anti Bait CoIP	20972224
Intra	E2F1	Q01094	KAT2A	Homo sapiens	Q92830	BioID	35140242
Intra	E2F1	Q01094	KAT2A	Homo sapiens	Q92830	Anti Bait CoIP	24502362
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Affinity Chrom	35140242
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Anti Bait CoIP	20871633
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Anti Tag CoIP	34591642
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Anti Bait CoIP	17380128
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	ITC	16360038
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Anti Bait CoIP	19249677
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Y2H	29521627
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Pull Down	16374512
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	SPR	12502741
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Anti Tag CoIP	17380128
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	X-Ray Diffraction	16360038
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	Pull Down	16360038
Intra	E2F1	Q01094	RB1	Homo sapiens	P06400	BioID	35140242
Intra	E2F1	Q01094	PAWR	Homo sapiens	Q96IZ0	Anti Tag CoIP	18660514
Intra	E2F1	Q01094	PAWR	Homo sapiens	Q96IZ0	Anti Bait CoIP	18660514
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Anti Tag CoIP	22327218
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Pull Down	22327218
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	ITC	16360038
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Y2H Array	20211142
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Anti Tag CoIP	34591642
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	BioID	35140242
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	X-Ray Diffraction	16360038
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Affinity Chrom	35140242
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	NMR	16360038
Intra	E2F1	Q01094	TFDP1	Homo sapiens	Q14186	Pull Down	16360038
Cross	E2F1	Q01094	E7	Human papillomavirus	P03129	Pull Down	11713253
Cross	E2F1	Q01094	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
Cross	E2F1	Q01094	E7	Human papillomavirus	P03129	Anti Tag CoIP	11713253
Intra	E2F1	Q01094	BTG3	Homo sapiens	Q14201	Anti Bait CoIP	17690688
Intra	E2F1	Q01094	BTG3	Homo sapiens	Q14201	Pull Down	17690688
Intra	E2F1	Q01094	BTG3	Homo sapiens	Q14201	Anti Tag CoIP	17690688

Cross: Cross-species interaction Intra: Intraspecies interaction

E2F1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80491	E2F-1 Antibody (YA471)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P84456	E2F-1 Antibody (YA4153)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84456A	E2F-1 Antibody (YA4153)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P85613	E2F-1 Antibody (YA5305)	WB, ICC/IF, IP	Human, Rat
HY-P86428	E2F-1 Antibody (YA6120)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Epilepsy, Idiopathic Generalized 3	EIG3 Idiopathic Generalized Epilepsy 3 Epilepsy, Idiopathic Generalized, Susceptibility To, 3 Epilepsy, Idiopathic Generalized Locus On Chromosome 9 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 9 Epilepsy, Idiopathic Generalized, Susceptibility To 3
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Pharyngoconjunctival Fever	Pharyngo-Conjunctival Fever Adenoviral Pharyngoconjunctivitis Adenovirus Infections, Human
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Atrophy Of Testis	Atrophic Testicle Atrophy Of Testicle Testicular Atrophy
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Bilateral Retinoblastoma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Soft Palate Cancer	Malignant Tumor Of Soft Palate Malignant Tumor Of The Soft Palate Palate Cancer Soft Palate
Sensory System Disease
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-16270	Kevetrin		/	Phase 2
HY-183118	CID-078		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-156135	NSC194598		98.90%	Unkown
HY-162384	EPIC-0628	Inhibitor	98.66%	Unkown
HY-148880	VHLL-BCN		96.30%	Unkown
HY-117857	MRT00033659		99.77%	Unkown
HY-RS04110	E2F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123612	JAS239	Inhibitor	/	Unkown
HY-175397	Dth		/	Unkown
HY-182902	IHMT-15137		/	Unkown
HY-RS15353	UBE2L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17052	E2f1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23496	E2f1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	E2F1	RGD	RGD:728892
Macaca mulatta	E2F1	VGNC	VGNC:72022
Mus musculus	E2F1	MGD	MGI:101941
Felis catus	E2F1	VGNC	VGNC:61694
Bos taurus	E2F1	VGNC	VGNC:28286
Others	E2F1	NCBI