MYCN - MYCN proto-oncogene, bHLH transcription factor Gene

Also Known as NMYC; ODED; MODED; N-myc; bHLHe37; MYCNsORF; MYCNsPEP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4613

About MYCN

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:15,940,550-15,947,004 (from NCBI)

This gene has 3 transcripts (splice variants), 218 orthologues, 2 paralogues and is associated with 86 phenotypes. Broad expression in placenta (RPKM 4.0), ovary (RPKM 2.1) and 14 other tissues.

Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

MYCN Products (4)

mRNA	Protein	Name
NM_001293228.2	NP_001280157.1	N-myc proto-oncogene protein isoform 1
NM_001293231.2	NP_001280160.1	N-myc proto-oncogene protein isoform 2
NM_001293233.2	NP_001280162.1	N-myc proto-oncogene protein isoform 3
NM_005378.6	NP_005369.2	N-myc proto-oncogene protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17327229	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17327229	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	27837025	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10597290	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	21796614	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24391509	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23308108	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17327229	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	10597290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYCN Protein Structure

Myc_N

HLH

0
100
200
300
400
464 a.a.

Protein Preferred Names	Protein Names
N-myc proto-oncogene protein	class E basic helix-loop-helix protein 37

MYCN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MYCN	P04198	SIRT1	Homo sapiens	Q96EB6	Pull Down	21698133
Intra	MYCN	P04198	ZBTB17	Homo sapiens	Q13105	Anti Bait CoIP	26766587
Intra	MYCN	P04198	ZBTB17	Homo sapiens	Q13105	Anti Tag CoIP	26766587
Intra	MYCN	P04198	NMI	Homo sapiens	Q13287	Y2H	10597290
Intra	MYCN	P04198	NMI	Homo sapiens	Q13287	Beta Galactosidase	10597290
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	Anti Bait CoIP	25175806
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	PLA	27728805
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	Anti Bait CoIP	23792191
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	Anti Bait CoIP	27728805
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	Anti Tag CoIP	23792191
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	PLA	23792191
Intra	MYCN	P04198	AURKA	Homo sapiens	O14965	Anti Bait CoIP	19111882
Intra	MYCN	P04198	CDKN2A	Homo sapiens	Q8N726	Imaging	17289033
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Anti Bait CoIP	18003922
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Anti Bait CoIP	27728805
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Anti Bait CoIP	25175806
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Y2H	10597290
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Anti Bait CoIP	23792191
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	Beta Galactosidase	10597290
Intra	MYCN	P04198	MAX	Homo sapiens	P61244	PLA	23792191

Cross: Cross-species interaction Intra: Intraspecies interaction

MYCN Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83939	MYCN Antibody (YA3636)	IHC-P, FC, ELISA	Human
HY-P83939A	MYCN Antibody (YA3636)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Feingold Syndrome 1	Feingold Syndrome Oculodigitoesophagoduodenal Syndrome Oded Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum FGLDS1 Mmt Syndrome Brunner-Winter Syndrome Feingold Syndrome Type 1 Oded Moded Fglds Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Moded Syndrome Oculo-Digito-Esophageal-Duodenal Syndrome Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome Microcephaly And Digital Abnormalities With Normal Intelligence Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Oculo-Digito-Esophagoduodental Syndrome Fs Mmt Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Brunner-Winter Syndrome Type 1 Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1 Fs1 Mmt Type 1 Moded Syndrome Type 1 Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1 Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1 Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1 Oded Syndrome Type 1 Oculo-Digito-Esophageal-Duodenal Syndrome Type 1 Feingold Syndrome, Type 1
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Cerebral Primitive Neuroectodermal Tumor	Pnet Of Cerebrum
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Ganglioneuroblastoma
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Peripheral Nervous System Benign Neoplasm
Autonomic Nervous System Benign Neoplasm
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Adrenal Neuroblastoma	Neuroblastoma Of Adrenal Gland Adrenal Gland Neuroblastoma Neuroblastoma Nos
Unilateral Retinoblastoma
Nodular Ganglioneuroblastoma	Ganglioneuroblastoma, Nodular
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
Cervical Neuroblastoma
Ganglioneuroma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Blastoma	Embryoma
Extracranial Neuroblastoma
Autonomic Nervous System Neoplasm	Tumor Of Autonomic Nervous System
Peripheral Nervous System Neoplasm	Peripheral Nervous System Neoplasms Nerve Sheath Neoplasm Neoplasm Of Peripheral Nerve Tumor Of Pns Nerve Sheath Neoplasms Nerve Sheath Tumors
Rhabdomyosarcoma
Spinal Ependymoma, Mycn-Amplified	Spinal Ependymoma, Mycn Spinal Cord Ependymoma, Mycn Amplified
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Horner'S Syndrome	Horner Syndrome Bernard-Horner Syndrome Oculosympathetic Palsy Bernard Horner Syndrome Cervical Sympathetic Paralysis Von Passow Syndrome Cervical Sympathetic Dystrophy
Bilateral Retinoblastoma
Desmoplastic Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity Nodular Medulloblastoma Desmoplastic/Nodular Medulloblastoma Mben Medulloblastoma, With Extensive Nodularity
Large Cell Medulloblastoma
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Intraocular Retinoblastoma	Pediatric Intraocular Retinoblastoma
Differentiating Neuroblastoma
Retroperitoneal Neuroblastoma
Adult Medulloblastoma	Adult Brain Medulloblastoma Medulloblastoma, Adult
Mismatch Repair Cancer Syndrome 1	Turcot Syndrome Constitutional Mismatch Repair Deficiency Syndrome Mismatch Repair Deficiency Mmr Deficiency MMRCS1 Cmmrds Childhood Cancer Syndrome Brain Tumor-Polyposis Syndrome 1 Btps1 Btp1 Syndrome Mismatch Repair Cancer Syndrome Childhood Cancer Brain Tumor-Polyposis Syndrome Cns Tumors With Familial Polyposis Of The Colon Glioma-Polyposis Syndrome Mmrcs Malignant Tumors Of The Central Nervous System Associated With Familial Polyposis Of The Colon Biallelic Mismatch Repair Deficiency Syndrome Bmmrd Cmmr-D Syndrome
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Charcot-Marie-Tooth Disease, Type 4d	Charcot-Marie-Tooth Disease Type 4d CMT4D Hmsnl Hmsn4d Charcot-Marie-Tooth Neuropathy Type 4d Hereditary Motor And Sensory Neuropathy Lom Type Hmsn-Lom Neuropathy, Hereditary Motor And Sensory, Lom Type Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d Charcot-Marie-Tooth Neuropathy, Type 4d Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d Hmsn Lom Type Hmsn, Lom Type Hereditary Motor And Sensory Neuropathy, Lom Type Charcot-Marie-Tooth Disease 4d Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d Hereditary Motor And Sensory Neuropathy Ivd Hmsn Ivd
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Megalencephaly	Macroencephaly Macrencephaly
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Extraocular Retinoblastoma	Pediatric Extraocular Retinoblastoma
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered	Ependymoblastoma
Hepatoblastoma
Central Nervous System Neuroblastoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Medulloepithelioma	Diktyoma, Malignant Medulloepithelioma, Central Nervous System Medulloepithelioma Of The Central Nervous System
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Central Nervous System Germ Cell Tumor	Central Nervous System Germ Cell Tumour Germ Cell Tumor Of The Cns Germ Cell Tumour Of The Cns
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Cns Neuroblastoma With Foxr2 Activation	Central Nervous System Neuroblastoma With Foxr2 Activation Cns Nb-Foxr2 Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Cerebellar Medulloblastoma
Sweeney-Cox Syndrome	SWCOS
Spinal Cord Ependymoma	Ependymal Neoplasm Of The Spinal Cord Spinal Ependymoma Ependymoma Of Spinal Cord
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Myxopapillary Ependymoma	Ependymoma Myxopapillary
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Duodenal Atresia	Duodenal Stenosis Familial Duodenal Atresia
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Frontal Lobe Neoplasm	Neoplasm Of Frontal Lobe Malignant Neoplasm Of Frontal Lobe Tumor Of Frontal Lobe
Histone Mutated Tumor	Histone Mutated Tumour
Cerebellum Cancer	Cerebellar Neoplasms Cerebellar Cancer Malignant Tumor Of Cerebellum Malignant Neoplasm Of Cerebellum
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Microphthalmia, Syndromic 3	MCOPS3 Aeg Syndrome Microphthalmia And Esophageal Atresia Syndrome Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome Anophthalmia-Esophageal-Genital Syndrome Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System Syndromic Microphthalmia 3 Sox2 Anophthalmia Syndrome Anophthalmia Clinical With Associated Anomalies Anophthalmia Esophageal Genital Syndrome Anophthalmia Microphthalmia Esophageal Atresia Syndromic Microphthalmia Type 3 Sox2-Related Eye Disorders Anophthalmia, Clinical, With Associated Anomalies Syndromic Microphthalmia, Type 3 Microphthalmia, Syndromic, 3 Anophthalmia/Microphthalmia-Esophageal Atresia Microphthalmia Syndromic, Type 3
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Syndromic Intellectual Disability
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-11103	Sitaxsentan sodium		98.83%	Unkown

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-117286	(S)-JQ-35		99.46%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-145765	JQAD1		98.24%	Unkown
HY-156443	YG1702	Inhibitor	99.94%	Unkown
HY-124447	BTYNB		98.0%	Unkown
HY-112273	CD532	Inhibitor	98.86%	Unkown
HY-144878	VPC-70619	Inhibitor	99.93%	Unkown
HY-171767	SK2188		99.87%	Unkown
HY-171768	SK2187	Degrader	95.81%	Unkown
HY-168439	HLB-0532259	Degrader	98.30%	Unkown
HY-112273A	CD532 hydrochloride	Inhibitor	99.62%	Unkown
HY-171769	dAurAB2	Degrader	98.61%	Unkown
HY-158062	LC-1-40		/	Unkown
HY-152032	LSD1-IN-23	Inhibitor	/	Unkown
HY-179375	LCI133	Inhibitor	/	Unkown
HY-179640	SK4454	Degrader	/	Unkown
HY-179641	SK5527	Degrader	/	Unkown
HY-181442	CK2-TN03		98.02%	Unkown
HY-181601	NPD15261	Inducer	/	Unkown
HY-186247	N-Myc-IN-1	Inhibitor	/	Unkown
HY-RS08884	MYCN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181568	PROTAC Aurora A Degrader-1		/	Unkown
HY-RS17293	Mycn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23748	Mycn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYCN	RGD	RGD:1584995
Bos taurus	MYCN	VGNC	VGNC:106830
Macaca mulatta	MYCN	VGNC	VGNC:106187
Mus musculus	MYCN	MGD	MGI:97357
Others	MYCN	NCBI