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ERGIC3 - ERGIC and golgi 3 Gene

Also Known as Erv46; CGI-54; C2orf47; PRO0989; C20orf47; NY-BR-84; SDBCAG84; dJ477O4.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51614

About ERGIC3

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,542,078-35,557,634 (from NCBI)

This gene has 19 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 113.7), testis (RPKM 112.2) and 25 other tissues.

Summary

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ERGIC3 Products (2)

mRNA	Protein	Name
NM_015966.3	NP_057050.1	endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform b
NM_198398.2	NP_938408.1	endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15308636	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	31142615	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	31142615	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of retrograde transporter complex, Golgi to ER	IPI IPI: Inferred from physical interaction	31142615	GOA
part of transporter complex	IPI IPI: Inferred from physical interaction	31142615	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERGIC3 Protein Structure

ERGIC_N

COPIIcoated_ERV

0
100
200
300
383 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum-Golgi intermediate compartment protein 3	endoplasmic reticulum-localized protein ERp43

ERGIC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ERGIC3	Q9Y282	MARCHF2	Homo sapiens	Q9P0N8	Anti Tag CoIP	31142615
Intra	ERGIC3	Q9Y282	HP	Homo sapiens	P00738	Anti Bait CoIP	31142615
Intra	ERGIC3	Q9Y282	SFXN5	Homo sapiens	Q8TD22	Anti Tag CoIP	33961781
Intra	ERGIC3	Q9Y282	VMP1	Homo sapiens	Q96GC9	Anti Tag CoIP	33961781
Intra	ERGIC3	Q9Y282	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	TMEM222	Homo sapiens	Q9H0R3	Y2H Prey Pooling	32296183
Intra	ERGIC3	Q9Y282	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	ERGIC2	Homo sapiens	Q96RQ1	Anti Tag CoIP	31142615
Intra	ERGIC3	Q9Y282	ERGIC2	Homo sapiens	Q96RQ1	Anti Tag CoIP	33961781
Intra	ERGIC3	Q9Y282	UNC50	Homo sapiens	Q53HI1	Y2H Array	32296183
Intra	ERGIC3	Q9Y282	ERGIC1	Homo sapiens	Q969X5	Anti Tag CoIP	31142615
Intra	ERGIC3	Q9Y282	ERGIC1	Homo sapiens	Q969X5	IF	15308636
Intra	ERGIC3	Q9Y282	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183
Intra	ERGIC3	Q9Y282	SERPINA1	Homo sapiens	P01009	Anti Bait CoIP	31142615
Intra	ERGIC3	Q9Y282	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 33	IMD33 X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency X-Linked Msmd Due To Ikbkg Deficiency X-Linked Msmd Due To Nemo Deficiency Invasive Pneumococcal Disease, Recurrent Isolated, 2 Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly Ipd2, Formerly Nf-Kappa B Essential Modulator Deficiency Familial X-Linked 1 Atypical Mycobacteriosis Nemo Deficiency Syndrome Amcbx1 Familial, X-Linked, Atypical Mycobacteriosis 1 Ipd2 Recurrent Isolated Invasive Pneumococcal Disease 2 X-Linked Disseminated Atypical Mycobacterial Infection Type 1 X-Linked Immunodeficiency 33, Mycobacteriosis X-Linked Susceptibility To Mycobacterial Disease Type 1 Invasive Pneumococcal Disease, Recurrent Isolated, Type 2 Atypical Mycobacteriosis, Familial, X-Linked 1
Alpha Thalassemia-Intellectual Disability Syndrome Type 1	Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16 Atr Syndrome Linked To Chromosome 16 Atr Syndrome, Deletion Type Atr-16 Syndrome Alpha Thalassemia-Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type Alpha-Thalassemia/Mental Retardation Syndrome, Type 1 Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-16915	RPR-260243	Activator	99.37%	Unkown
HY-RS04494	ERGIC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ERGIC3	VGNC	VGNC:72274
Rattus norvegicus	ERGIC3	RGD	RGD:1308144
Mus musculus	ERGIC3	MGD	MGI:1913616
Bos taurus	ERGIC3	VGNC	VGNC:28580
Canis familiaris	ERGIC3	VGNC	VGNC:40452
Felis catus	ERGIC3	VGNC	VGNC:61941
Others	ERGIC3	NCBI