GNE-5152
GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research.
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- CAS. Nr.: 3080315-83-6
- Formel: C21H17F2N3O
- Molecular Weight:365.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 3080315-83-6
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Molecular Weight 365.38
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Formel C21H17F2N3O
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SMILES
O=C1N(CCC(C1)C2=CC=C(C(F)=C2)F)C3=CC=C(C4=CC=NC=C4)N=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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