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Gocatamig

(Synonyms: MK-6070; HPN328)
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Gocatamig is a (scFv-heavy-lamdba)-VH-VH'-type chimeric humanized antibody targeting CD3E/ALB/DLL3. Gocatamig binds DLL3 on tumor cells, recruits T cells, induces T cell-mediated cytotoxicity, and redirects T cells to mediate antitumor activity. Gocatamig can be used in research related to small cell lung cancer, prostate cancer, and neuroendocrine tumors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit : ≥99.0%
  • CAS. Nr.: 2851862-91-2
  • Molecular Weight:53.058 kDa
  • Speicherung:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Gocatamig
  • Experimental Validation Results for Gocatamig
  • Experimental Validation Results for Gocatamig
  • Experimental Validation Results for Gocatamig
  • Gocatamig Chemical Structure
    Gocatamig Chemical Structure
CAS. Nr.: 2851862-91-2
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    scFvhl-VH-VH

  • 1/16

    Loaded Gocatamig on AHC2 biosensor, can bind Delta-like protein 3/DLL3 Protein, Human (HEK293, His, HY-P700456) with an affinity constant of 4.341E-09 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Gocatamig (HY-P990920, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow Cytometry analysis of Hela cells labelling DLL3 (red) with Gocatamig (HY-P990920). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).

  • Gocatamig Chemical Structure
    1/16
  • Gocatamig
  • Loaded Gocatamig on AHC2 biosensor, can bind Delta-like protein 3/DLL3 Protein, Human (HEK293, His, HY-P700456) with an affinity constant of 4.341E-09 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 Juakat cells with Gocatamig (HY-P990920, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow Cytometry analysis of Hela cells labelling DLL3 (red) with Gocatamig (HY-P990920). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).
  • scFvhl-VH-VH