GRL-8234
GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD).
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- CAS. Nr.: 913071-81-5
- Formel: C36H42N4O6S
- Molecular Weight:658.81
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.001 μM
Compound: 24, GRL-8234
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Inhibition of memapsin 2 expressed in CHO cells
Inhibition of memapsin 2 expressed in CHO cells
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[PMID: 18180160] |
Chemical Information
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CAS. Nr. 913071-81-5
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Molecular Weight 658.81
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Formel C36H42N4O6S
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SMILES
O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GRL-8234 Related Classifications
HY-10104 Related Classifications
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