Herbicidin A
Herbicidin A is an adenosine-derived nucleoside antibiotic, but also is a herbicide against dicotyledonous plants. Herbicidin A can be isolated from Streptomyces scopuliridis M40.
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- CAS. Nr.: 55353-31-6
- Formel: C23H29N5O11
- Molecular Weight:551.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
>25 μM
Compound: 2
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Cytotoxicity against human HCT8 cells
Cytotoxicity against human HCT8 cells
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[PMID: 29469575] |
| HEK293 | IC50 |
1.8 μM
Compound: 4
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Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay
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[PMID: 24533857] |
| HEK293 | IC50 |
2.7 μM
Compound: 4
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Cytotoxicity against HEK293 cells
Cytotoxicity against HEK293 cells
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[PMID: 24533857] |
| HEK-293T | CC50 |
>40 μM
Compound: 2
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Cytotoxicity against human HEK293T cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay
Cytotoxicity against human HEK293T cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay
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[PMID: 29469575] |
| HepG2 | CC50 |
>40 μM
Compound: 2
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Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay
|
[PMID: 29469575] |
In Vitro
Herbicidin A is the most extensively decorated herbicidin to date, which has a 5-hydroxytiglyl group at C8[1].
The precursors for herbicidin biosynthesis are D-glucose, D-ribose, Lisoleucine, and L-methionine[1].
Herbicidins are selective herbicide against dicotyledonous plants and inhibit the germination of Chinese cabbage and rice seeds[1].
Herbicidins can protect rice plants from leaf blight and also exhibit antialgal and antifungal activities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 55353-31-6
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Molecular Weight 551.50
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Formel C23H29N5O11
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SMILES
O[C@]12[C@@](O[C@@H]([C@H]([C@@H]2OC(/C(CO)=C/C)=O)O)C(OC)=O)([H])C[C@]3([H])[C@]([C@H]([C@H](N4C5=NC=NC(N)=C5N=C4)O3)OC)([H])O1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Lin GM, et al. Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic. J Am Chem Soc. 2017 Nov 22;139(46):16450-16453. [Content Brief]
[2]. Ha S, et al. Optimization of Herbicidin A Production in Submerged Culture of Streptomyces scopuliridis M40. J Microbiol Biotechnol. 2017 May 28;27(5):947-955. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Herbicidin A Related Classifications
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