country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-157838

Copy Link Print Information

HMC-B17

HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC₅₀ = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC₅₀ = 11.56 nM). HMC-B17 can be used for the research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2935913-83-8
Formel: C₂₇H₂₉N₃O₂
Molecular Weight:427.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HMC-B17 Chemical Structure

CAS. Nr.: 2935913-83-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle MAP4K Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BEAS-2B	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
Jurkat	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
L02	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
MCF-10A	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
WRL68	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]

Chemical Information

CAS. Nr. 2935913-83-8
Molecular Weight 427.54
Formel C₂₇H₂₉N₃O₂
SMILES

COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zeng S, et al. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody. Eur J Med Chem. 2024 Mar 5;267:116206. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

HMC-B17

Alle MAP4K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HMC-B17 Related Classifications

HY-157838 Related Classifications