Art. -Nr.: HY-153585

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IK-930

5 Cited Publications

Kundenbewertung

Based on 5 publication(s) in Google Scholar

IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC₅₀ value of <0.1 µM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.39%
CAS. Nr.: 2563892-44-2
Formel: C₁₉H₁₉F₃N₄O₂S
Molecular Weight:424.44

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IK-930 Chemical Structure

CAS. Nr.: 2563892-44-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (5)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC₅₀ value of <0.1 µM^[1].

IC₅₀ & Target

TEAD^[1]

Alle YAP Isoform-spezifische Produkte anzeigen :

In Vivo

IK-930 (compound I-32) (10 mg/kg; p.o.) shows good pharmacokinetic parameters with C_max of 1088 ng/mL, AUC 0-last of 4581 ng*h/mL in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 2563892-44-2
Appearance Solid
Molecular Weight 424.44
Formel C₁₉H₁₉F₃N₄O₂S
Color White to off-white
SMILES

O=S(NC)(C1=CC(C2=CN(C)C=N2)=C(NCC3=CC=C(C(F)(F)F)C=C3)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (5)

All Cell Proliferation/Viability AssayCell Imaging/StainingRT-PCR

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Journal Impact Factor

Nat Mater

2026 Feb 20.

IK-930 purchased from MedChemExpress. Usage Cited in: Nat Mater. 2026 Feb 20.

IK-930 (0-100 μM; 48 h) inhibited cell viability in NC and VFC T1 and T3 cells.

IK-930 purchased from MedChemExpress. Usage Cited in: Nat Mater. 2026 Feb 20.

IK-930 (30 μM; 48 h) showed representative phase contrast images in NC and VFC T1 and T3 cells.
Mol Cell

Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response. [Abstract]

2025 Sep 18;85(18):3425-3442.e10. PMID: 40914169
Res Sq

2026 Jun 17.
Comput Biol Med

DrugAppy - An end-to-end deep learning framework for computational drug discovery. [Abstract]

2025 Oct 18;198(Pt B):111201. PMID: 41110298

IK-930 purchased from MedChemExpress. Usage Cited in: Comput Biol Med. 2025 Oct 18;198(Pt B):111201. [Abstract]

IK-930 (0-100 μM) inhibited cell viability with IC50 in the range of 25–158 μM.

IK-930 purchased from MedChemExpress. Usage Cited in: Comput Biol Med. 2025 Oct 18;198(Pt B):111201. [Abstract]

IK-930 (10 μM; 6 days) inhibited cell viability HNSCC cells. Crystal violet cell viability assay of HNSCC cells untreated (Control), treated with vehicle (DMSO) or with 10 μM of TEAD inhibitors for 6 days.

IK-930 purchased from MedChemExpress. Usage Cited in: Comput Biol Med. 2025 Oct 18;198(Pt B):111201. [Abstract]

IK-930 decreased the mRNA expression of CYR61 and CTGF in detrolt-562 and Fadu cells.
bioRxiv

EHE cell cultures: a platform for mechanistic and therapeutic investigation. [Abstract]

2025 Mar 27:2025.03.24.644191. PMID: 40196670

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (235.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3560 mL

11.7802 mL

23.5605 mL

5 mM

0.4712 mL

2.3560 mL

4.7121 mL

10 mM

0.2356 mL

1.1780 mL

2.3560 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Alfredo C. Castro, et al. Tead inhibitors and uses thereof. WO2020243415A2.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3560 mL	11.7802 mL	23.5605 mL	58.9011 mL
	5 mM	0.4712 mL	2.3560 mL	4.7121 mL	11.7802 mL
	10 mM	0.2356 mL	1.1780 mL	2.3560 mL	5.8901 mL
	15 mM	0.1571 mL	0.7853 mL	1.5707 mL	3.9267 mL
	20 mM	0.1178 mL	0.5890 mL	1.1780 mL	2.9451 mL
	25 mM	0.0942 mL	0.4712 mL	0.9424 mL	2.3560 mL
	30 mM	0.0785 mL	0.3927 mL	0.7853 mL	1.9634 mL
	40 mM	0.0589 mL	0.2945 mL	0.5890 mL	1.4725 mL
	50 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1780 mL
	60 mM	0.0393 mL	0.1963 mL	0.3927 mL	0.9817 mL
	80 mM	0.0295 mL	0.1473 mL	0.2945 mL	0.7363 mL
	100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5890 mL

Keywords

IK-930

5 Cited Publications

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IK-930

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Anti-Cancer Compound Library

Clinical Compound Library

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Orally Active Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Bioactive Compound Library Max

Anti-Aging Compound Library Mini

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IK-930

Alle YAP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (5)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IK-930

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Bioactive Compound Library Max

Anti-Aging Compound Library Mini

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IK-930

Alle YAP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (5)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IK-930 Related Classifications

HY-153585 Related Classifications