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Art. -Nr.: HY-W471288

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JPC0661

JPC0661 is a direct and allosteric ΔFOSB inhibitor. JPC0661 inhibits the binding of ΔFOSB/JUND and ΔFOsB to DNA with IC₅₀ values in the micromolar range (9-52 uM), directly inhibits ΔFOSB-mediated transcription with IC₅₀ of 0.82 μM in vitro. JPC0661 significantly reduces ΔFOSB occupancy at genomic AP1 sites in vivo. JPC0661 binds to a novel groove outside the DNA-binding cleft of ΔFOSB and disrupt the formation of the ΔFOSB/JUND-DNA complex. JPC0661 can be used for Alzheimer's disease research.

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CAS. Nr.: 30479-81-3
Formel: C₁₅H₁₃N₃O₅S
Molecular Weight:347.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

JPC0661 Chemical Structure

CAS. Nr.: 30479-81-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

FosB

Alle AP-1 Isoform-spezifische Produkte anzeigen :

In Vitro

JPC0661 (0-100 μM) regulate ΔFOSB-driven gene expression with IC₅₀ of 0.82 μM and accumulates ΔFOSB protein in HEK293 cells^[1].
JPC0661 (0-100 μM, 24 or 72 h) has good tolerance in neuronal progenitor cells, AP1-luc HEK293 cells and d Neuro2A cells (NPC) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Neuronal progenitor cells (NPC)
Concentration:

0.16, 0.31, 0.63, 1.25, 2.5, 5.00, 10.00 and 20 μM,
Incubation Time:

24,72 h
Result:

Observed no discernable decrease after 24 h and only minimal losses after 72 h.

In Vivo

JPC0661 (50 μM , 16.7 ng/h, intra-hippocampal infusion, for 3 days ) causes a robust, broad reduction in ΔFOSB binding across most this transcription factor’s normal genomic locations in heterozygous transgenic male and female mice expressing human amyloid precursor protein (APP) carrying Swedish (K670N, M671L) and Indiana (V717F) mutations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Heterozygous transgenic male and female mice (2-3 months)^[1]
Dosage:

50 μM in 0.2% DMSO/0.9% saline with 0.96 μL/h
Administration:

intra-hippocampal infusion for 3 days
Result:

Exhibited an approximately 60% reduction in total binding sites.
Decreased average peak width.
Directly disrupted ΔFOSB–DNA interactions.
Caused a modest decline in promoter proximal peaks (≤1 kb) and a relative enrichment in distal intergenic peaks.

Chemical Information

CAS. Nr. 30479-81-3
Molecular Weight 347.35
Formel C₁₅H₁₃N₃O₅S
SMILES

O=C1N(C2=CC(S(=O)(O)=O)=C(OC3=CC=CC=C3)C=C2)N=C(N)C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. McNeme S, et al. Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor ΔFOSB. J Biol Chem. 2025 Dec 22:111080. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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JPC0661

Alle AP-1 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

JPC0661 Related Classifications

HY-W471288 Related Classifications