JWG-045
JWG-045 is a selective ERK5 inhibitor. JWG-045 exhibits unique ferroptosis-resistant activity independent of ERK5 inhibition. JWG-045 can be used in breast cancer research.
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- CAS. Nr.: 1234480-61-5
- Formel: C27H33N7O2
- Molecular Weight:487.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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ERK5 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.23 μM
Compound: 24
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Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis
Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis
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[PMID: 21412406] |
JWG-045 (3 μM; 24 h) reduces cell density modestly in BT474 cells and protects both BT474 and MDA-MB-231 breast cancer cells from RSL3-induced ferroptotic cell death[1].
JWG-045 (3 μM; 24 h) protects ERK5-silenced MDA-MB-231 triple-negative breast cancer cells from RSL3-induced ferroptosis independently of ERK5 expression[1].
JWG-045 (3 μM; 6 days) reduces cell density in Trastuzumab (HY-P9907)-resistant BT474 breast cancer cells and restores sensitivity to Trastuzumab[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT474 luminal B breast cancer cells, MDA-MB-231 triple-negative breast cancer cells
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Concentration:3 μM (single treatment; pre-incubated then combined with RSL3)
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Incubation Time:24 h (single treatment; total incubation with RSL3); 20 h (live-cell imaging)
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Result:Caused a modest, statistically significant reduction in BT474 cell density.
Reduced RSL3-induced cytotoxicity in both BT474 and MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.
Prevented the time-dependent decrease in BT474 cell confluency induced by RSL3 over 20 hours.
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Cell Line:ERK5-silenced MDA-MB-231 triple-negative breast cancer cells
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Concentration:3 μM (alone; combined with RSL3)
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Incubation Time:24 h
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Result:Blocked RSL3-induced ferroptotic death in both control and ERK5-silenced MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.
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Cell Line:Trastuzumab-resistant BT474 breast cancer cells
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Concentration:3 μM (alone; combined with Trastuzumab)
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Incubation Time:6 days
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Result:Reduced BT474 cell density.
Restored the growth inhibitory effect of trastuzumab in Trastuzumab-resistant BT474 cells to the level achieved by Trastuzumab monotherapy in parental BT474 cells.
Chemical Information
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CAS. Nr. 1234480-61-5
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Molecular Weight 487.60
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Formel C27H33N7O2
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SMILES
O=C(N(C1=CN=C(N=C12)NC3=CC=C(C=C3OC)N4CCN(CC4)C)C)C5=CC=CC=C5N2C(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
JWG-045 Related Classifications
HY-181968 Related Classifications
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