KMUP-4
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases.
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- CAS. Nr.: 864873-81-4
- Formel: C19H23N7O4
- Molecular Weight:413.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
KMUP-4 (1 nM-100 μM) produces concentration-dependent vasorelaxant effects on deendothelial aortas (E2) (pEC50=5.94) and intact endothelial aortas (E+) (PEC50=6.45), indicating that the vasodilatory effect of KMUP-4 is partially dependent on endothelial cells[1]. KMUP-4 (10 μM) shows 56%, 33% and 15% inhibitory activity against PDE3, PDE4 and PDE5 in HUVECs[1]. KMUP-4 (0.1 μM, 18 h) increases significantly the expression of eNOS protein in HUVECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 864873-81-4
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Molecular Weight 413.43
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Formel C19H23N7O4
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SMILES
O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KMUP-4 Related Classifications
HY-129210 Related Classifications
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