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Art. -Nr.: HY-148200

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L2H2-6OTD

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM.

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CAS. Nr.: 1016263-75-4
Formel: C₃₀H₃₀N₁₀O₈
Molecular Weight:658.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

L2H2-6OTD Chemical Structure

CAS. Nr.: 1016263-75-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.4 μM Compound: fig. 9, R1C3-1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	10.1039/C0MD00241K
KB 3-1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay	[PMID: 20409709]
KB-V1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay	[PMID: 20409709]

Chemical Information

CAS. Nr. 1016263-75-4
Molecular Weight 658.62
Formel C₃₀H₃₀N₁₀O₈
SMILES

NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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L2H2-6OTD

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L2H2-6OTD Related Classifications

HY-148200 Related Classifications